The evolving landscape of glioblastoma stem cells.
The evolving landscape of glioblastoma stem cells.
复制标题
胶质母细胞瘤干细胞不断发展的景观。
DOI：
10.1097/wco.0000000000000032
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发表时间：
2013-12
影响因子：
4.8
通讯作者：
Rich JN
中科院分区：
文献类型：
--
作者：
Yan K;Yang K;Rich JN
本文将对近年来肿瘤干细胞（CSC）在胶质母细胞瘤（GBM）中的作用进行综述。自描述脑肿瘤CSCs以来的十年中，这些细胞在肿瘤生长、治疗抵抗和扩散中的潜在意义已经变得明显。最近，CSCs、肿瘤遗传学和微环境之间的相互作用为治疗开发提供了潜在的脆弱性节点。CSC的表型是由特定的受体信号传导决定的，通过转录因子和mirna对干细胞基因的调节已经确定了许多新的治疗靶点。像正常干细胞一样，CSC显示出特定的表观遗传景观和代谢谱。脑癌激活核心干细胞调控途径，以增强自我更新，维持器官系统（尽管是异常的），并在压力下存活，这些共同允许肿瘤生长，治疗抵抗，入侵和血管生成。这些特性暗示了CSC在GBM进展和复发中的作用，刺激了对不破坏正常干细胞维持的抗CSC疗法的研究。过去的一年见证了对CSC生物学的理解的快速发展，以告知临床前靶向。
Recent advances in the role of cancer stem cells (CSC) in glioblastoma (GBM) will be reviewed. In the decade since the description of brain tumor CSCs, the potential significance of these cells in tumor growth, therapeutic resistance and spread has become evident. Most recently, the interplay between CSCs, tumor genetics and the microenvironment has offered potential nodes of fragility under therapeutic development. The CSC phenotype is informed by specific receptor signaling, and the regulation of stem cell genes by transcription factors and miRNAs has identified a number of new targets amenable to treatment. Like normal stem cells, CSC display specific epigenetic landscapes and metabolic profiles. Brain cancers activate core stem cell regulatory pathways to empower self-renewal, maintenance of an organ system (albeit an aberrant one), and survival under stress that collectively permits tumor growth, therapeutic resistance, invasion and angiogenesis. These properties have implicated CSC as contributors in GBM progression and recurrence, spurring a search for anti-CSC therapies that do not disrupt normal stem cell maintenance. The past year has witnessed a rapid evolution in the understanding of CSC biology to inform preclinical targeting.