New membranes based on polyethersulfone – SlipSkin™ polymer blends with low fouling and high blood compatibility
New membranes based on polyethersulfone – SlipSkin™ polymer blends with low fouling and high blood compatibility
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DOI：
10.1016/j.seppur.2019.05.049
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发表时间：
2019-10
影响因子：
8.6
通讯作者：
O. T. Beek;D. Pavlenko;M. Suck;S. Helfrich;L. Bolhuis-Versteeg;D. Snisarenko;C. Causserand;P. Bacchin;P. Aimar;R. Oerle;R. Wetzels;P. Verhezen;Y. Henskens;D. Stamatialis
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文献类型：
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作者：
O. T. Beek;D. Pavlenko;M. Suck;S. Helfrich;L. Bolhuis-Versteeg;D. Snisarenko;C. Causserand;P. Bacchin;P. Aimar;R. Oerle;R. Wetzels;P. Verhezen;Y. Henskens;D. Stamatialis
血液透析是治疗终末期肾病（ESRD）的重要手段。这些患者每周去医院3次，每次他们的血液在4小时的透析过程中使用中空纤维膜模块进行净化;也称为人工肾。该装置主要实现小的水溶性毒素和有限数量的中分子的去除。为了改善毒素的清除，特别是中分子和蛋白质结合的毒素，需要通过夜间透析和/或应用便携式/可穿戴式人工肾进行更长时间的治疗。这种疗法需要应用具有非常低的结垢和非常好的血液相容性的膜。目前的膜通常含有亲水性添加剂，其在灭菌过程和/或长期过滤过程中可能会起泡。在这项研究中，我们提出了一种开发低污染血液相容性膜的简单方法，方法是将聚醚砜（PES）（一种已用于制造透析膜的材料）与少量SlipSkin™（SS）（一种亲水性N-乙烯基吡咯烷酮（NVP）和疏水性N-甲基丙烯酸丁酯（BMA）的血液相容性无规共聚物）混合。我们的研究结果表明，具有2重量%的SS的膜具有高的抗污染性的蛋白质和中等大小的分子和非常好的血液相容性，使这些膜有望在透析治疗中的应用。
Hemodialysis is an important therapy for treating patients with End Stage Renal Disease (ESRD). These patients visit the hospital 3 times a week and each time their blood is cleansed during 4-hour dialysis sessions using a hollow fiber membrane module; also called artificial kidney. This device mainly achieves removal of small water-soluble toxins and a limited number of middle molecules. To improve the clearance of toxins, especially middle molecules and protein bound toxins, longer treatment via nocturnal dialysis and/or the application of portable/wearable artificial kidney is required. Such therapies require application of membranes with very low fouling and very good blood compatibility. Current membranes often contain hydrophilic additives which could elute during sterilization processes and/or during long-term filtration. In this study, we propose a simple method for developing low fouling blood compatible membranes by blending of polyethersulfone (PES), a material already used for fabrication of dialysis membranes, with small amounts of SlipSkin™ (SS), a blood compatible random copolymer of hydrophilic N-vinylpyrrolidone (NVP) and hydrophobic N-butylmethacrylate (BMA). Our results show that membranes with 2 wt% of SS have high fouling resistance to proteins and middle-size molecules and very good blood compatibility, making these membranes promising for application in dialysis therapy.