Integrated multi-functional probe for active measurements in a single neural cell
Integrated multi-functional probe for active measurements in a single neural cell
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用于单个神经细胞主动测量的集成多功能探针
DOI：
10.1109/sensor.2005.1497301
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
I. Shimoyama
中科院分区：
文献类型：
--
作者：
S. Nagasawa;H. Arai;R. Kanzaki;I. Shimoyama
在本文中，我们提出了一个多功能的探针记录在一个活的单个神经细胞的生物活动。研究了一种以玻璃微注射器为多功能探针的主动式同时测量方法。利用时域有限差分法（FDTD）模拟了亚微米量级的测量区域。将原型装置应用于Aaplasia的颊神经节中的单个神经细胞。由于同时记录了电刺激引起的活动电位和钙浓度反应，因此证实了我们测量方法的有效性。
In this paper, we propose a multi-functional probe for recording biological activities in a living single neural cell. An active and simultaneous measurement method using a glass micro injector as a multi-functional probe was examined. A measurement region was estimated to be submicron order by using FDTD simulation. A prototype device was applied to a single neural cell in a buccal ganglion of Aplysia. Since active potentials and calcium concentration reactions induced by electric stimuli were recorded simultaneously, validity of our measurement method was confirmed.