Phosphoinositide turnover provides a link in stimulus—response coupling
Phosphoinositide turnover provides a link in stimulus—response coupling
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磷酸肌醇周转提供了刺激-反应耦合的联系
DOI：
10.1016/0968-0004(85)90160-4
复制
发表时间：
1985
影响因子：
13.8
通讯作者：
E. Neufeld
中科院分区：
文献类型：
--
作者：
P. Majerus;D. Wilson;T. Connolly;T. E. Bross;E. Neufeld
磷脂酰肌醇及其磷酸化衍生物是信使分子的储存形式，可以响应特定的细胞外信号而释放，这一发现引起了人们的极大兴奋。信号分子与细胞表面受体结合，由磷脂酰肌醇衍生的信使分子将信号与细胞内和细胞间的各种反应偶联。磷脂酰肌醇是一种次要的磷脂（约占磷脂的5%），其周转速度比其他膜脂质快得多。Hokin和Hokin是第一个观察到乙酰胆碱加速这种周转率的人，他们对胰腺组织的研究结果在从酵母、昆虫到人类的无数组织中反复观察。虽然已经提出了许多理论，但直到最近才证明了该过程的明确功能。类二十烷酸介体（花生四烯酸和相关多不饱和脂肪酸的含氧衍生物，如洋地黄素，
Much excitement has resulted from the discovery that phosphatidylinositol and its phosphorylated derivatives are storage forms of messenger molecules that can be released in response to specific extracellular signals. Signal molecules bind to cell surface receptors and the messenger molecules derived from the phosphoinositides couple the signal to a variety of responses within and between cells.Phosphoinositides are minor phospholipids (~ 5% of phospholipid) that turnover much more rapidly than other membrane lipids. Hokin and Hokin were the first to observe that acetylcholine accelerates this turnover rateL Their results with pancreatic tissue have since been observed repeatedly in a myriad of tissues from yeast and insects to man 2. Although many theories have been proposed, no clear function for the process was demonstrated until recently. The production of icosanoid mediators (oxygenated derivatives of arachidonic acid and related polyunsaturated fatty acids such as prostaglandins,
DOI：
10.1016/s0021-9258(18)33114-4
发表时间：
1983-01
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
S. Prescott;P. Majerus
通讯作者：
S. Prescott;P. Majerus
纯化的绵羊精囊磷脂酶 C 酶水解多磷酸肌醇。
DOI：
--
发表时间：
1984
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Wilson,DB;Bross,TE;Hofmann,SL;Majerus,PW
通讯作者：
Majerus,PW