The Role of Oxidative Stress in Neurodegenerative Diseases
The Role of Oxidative Stress in Neurodegenerative Diseases
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DOI：
10.1007/978-1-4939-0440-2_8
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Dominika Ksiazek-Winiarek;A. Głąbiński
中科院分区：
文献类型：
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作者：
Dominika Ksiazek-Winiarek;A. Głąbiński
神经退行性疾病如阿尔茨海默病（AD）、帕金森病（PD）、肌萎缩侧索硬化症（ALS）和多发性硬化症（MS）是与预期寿命增加相关的世界范围的健康和经济问题。这些疾病的确切病因尚不清楚。神经退行性疾病的病因是多因素的，包括表观遗传和环境因素的作用。已经提出，氧化应激相关的一些大分子损伤在其发病机制中起着关键作用。在这里，我们想修改目前的知识，活性氧（ROS）和氧化应激在神经系统疾病，如AD，PD，ALS和MS发生的神经退行性变中的作用。
Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) are worldwide health and economic problems related to increased life expectancy. The exact cause of the etiology of these disorders is not known. Neurodegenerative diseases are of multifactorial etiology, including the role of epigenetic and environmental factors. It has been proposed that oxidative stress–related damage of several macromolecules plays a key role in their pathogenesis. Here, we want to revise the current knowledge regarding the role of reactive oxygen species (ROS) and oxidative stress in neurodegeneration occurring in neurological diseases such as AD, PD, ALS, and MS.