GRAPHENE AS TUNABLE STATIONARY PHASE ADDITIVE FOR ENANTIOSEPARATION
GRAPHENE AS TUNABLE STATIONARY PHASE ADDITIVE FOR ENANTIOSEPARATION
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DOI：
10.1142/s1793292013500690
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发表时间：
2013-11
期刊：
影响因子：
1.2
通讯作者：
Fei‐yue Tu;Lin-Yan Yu;Jingang Yu;Xiaoqing Chen;Qiang Fu;F. Jiao;Zhiguang Peng;Ting Zhang
中科院分区：
文献类型：
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作者：
Fei‐yue Tu;Lin-Yan Yu;Jingang Yu;Xiaoqing Chen;Qiang Fu;F. Jiao;Zhiguang Peng;Ting Zhang
基于石墨烯的生物传感器和手性传感器近年来取得了重大进展。由于光学对映体的相似性，拆分对映体可能是最微妙的。开发更有效的基于石墨烯的手性分离技术是非常有必要的。本文制备了纯石墨烯，并将其应用于两种外消旋药物心得安和氧氟沙星的薄层色谱拆分。与仅用D-(-)-酒石酸作为选择剂的手性拆分相比，石墨烯和D-(-)-酒石酸的混合物更吸引人、更有效、更容易获得。石墨烯辅助外消旋化合物的高分辨能力可能使其在未来的手性分离技术中具有潜在的应用前景。
Graphene-based biosensor and chiral sensor have made significant progress in recent years. Because of the similarity of the optical enantiomers, enantioseparation is perhaps the most subtle to achieve. Developing more effectively chiral separation techniques based on graphene is highly desirable. Herein, pristine graphene was prepared and then applicated to assist resolution of two racemic drugs of propranolol and ofloxacin using thin-layer chromatography (TLC). In comparison with TLC chiral separation by only using pure D-(-)-tartaric acid as a selector with relatively low degree of separation, a mixture of graphene and D-(-)-tartaric acid is more attractive, efficient and ready available. The high specific resolution ability for racemic compounds aided by graphene might allow its potential application in future chiral separation technologies.