Biological action of leptin as an angiogenic factor
Biological action of leptin as an angiogenic factor
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DOI：
10.1126/science.281.5383.1683
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发表时间：
1998-09-11
期刊：
影响因子：
56.9
通讯作者：
Flores-Riveros, JR
中科院分区：
文献类型：
--
作者：
Sierra-Honigmann, MR;Nath, AK;Flores-Riveros, JR
瘦素是一种调节食物摄入的激素，其受体（OB-Rb）主要在下丘脑中表达。在这里，它表明OB-Rb也表达在人类血管系统和人类内皮线圈的原代培养物中，在体外和体内测定显示，瘦素具有血管生成活性。在体内，瘦素在正常大鼠的角膜中诱导新血管形成，但在缺乏功能性瘦素受体的fa/fa Zucker大鼠的角膜中不诱导新血管形成。这些观察结果表明，血管内皮是瘦素的目标，并提出了生理机制，瘦素诱导的血管生成可能有助于增加能量消耗。
Leptin is a hormone that regulates food intake, and its receptor (OB-Rb) is expressed primarily in the hypothalamus. Here, it is shown that OB-Rb is also expressed in human vasculature and in primary cultures of human endothelial coils, In vitro and in vivo assays revealed that Leptin has angiogenic activity. In vivo, Leptin induced neovascularization in corneas from normal rats but not in corneas from fa/fa Zucker rats, which Lack functional Leptin receptors. These observations indicate that the vascular endothelium is a target for Leptin and suggest a physiological mechanism whereby Leptin-induced angiogenesis may facilitate increased energy expenditure.