Regulation and Modulation of Human DNA Polymerase δ Activity and Function.
Regulation and Modulation of Human DNA Polymerase δ Activity and Function.
复制标题
DOI：
10.3390/genes8070190
复制
发表时间：
2017-07-24
期刊：
影响因子：
3.5
通讯作者：
Lee EYC
中科院分区：
文献类型：
--
作者：
Lee MYWT;Wang X;Zhang S;Zhang Z;Lee EYC
本文就人DNA聚合酶δ（Pol δ）的调控机制作一综述。重点是在DNA修复和复制中调节Pol δ的活性和性质的机制。所涵盖的领域是Pol δ的p12亚基的降解，其将其从异源四聚体（Pol δ4）转化为异源三聚体（Pol δ3），以响应DNA损伤和细胞周期。综述了导致p12降解的生化机制，以及Pol δ4和Pol δ3的性质，为深入了解它们在DNA复制和修复中的功能提供了依据。第二个重点是两个Pol δ结合蛋白的功能，聚合酶δ相互作用蛋白46（PDIP 46）和聚合酶δ相互作用蛋白38（PDIP 38），这两个蛋白都是多功能蛋白。PDIP 46是Pol δ4的一种新型激活剂，并讨论了该功能的影响与其在DNA复制中的潜在作用。提出了几种新的模型，用于研究Pol δ3和Pol δ4在前导链和滞后链DNA合成中的作用，这些模型整合了PDIP 46的作用。PDIP 38具有多个细胞定位，包括线粒体、剪接体和细胞核。它涉及许多细胞功能，包括调节专门的DNA聚合酶、有丝分裂、DNA损伤反应、小鼠双微体2同源物（Mdm 2）选择性剪接和调节NADPH氧化酶4（Nox 4）。
This review focuses on the regulation and modulation of human DNA polymerase δ (Pol δ). The emphasis is on the mechanisms that regulate the activity and properties of Pol δ in DNA repair and replication. The areas covered are the degradation of the p12 subunit of Pol δ, which converts it from a heterotetramer (Pol δ4) to a heterotrimer (Pol δ3), in response to DNA damage and also during the cell cycle. The biochemical mechanisms that lead to degradation of p12 are reviewed, as well as the properties of Pol δ4 and Pol δ3 that provide insights into their functions in DNA replication and repair. The second focus of the review involves the functions of two Pol δ binding proteins, polymerase delta interaction protein 46 (PDIP46) and polymerase delta interaction protein 38 (PDIP38), both of which are multi-functional proteins. PDIP46 is a novel activator of Pol δ4, and the impact of this function is discussed in relation to its potential roles in DNA replication. Several new models for the roles of Pol δ3 and Pol δ4 in leading and lagging strand DNA synthesis that integrate a role for PDIP46 are presented. PDIP38 has multiple cellular localizations including the mitochondria, the spliceosomes and the nucleus. It has been implicated in a number of cellular functions, including the regulation of specialized DNA polymerases, mitosis, the DNA damage response, mouse double minute 2 homolog (Mdm2) alternative splicing and the regulation of the NADPH oxidase 4 (Nox4).
登录
查看更多内容
影响因子：
3.7
作者：
Braithwaite EK;Kedar PS;Stumpo DJ;Bertocci B;Freedman JH;Samson LD;Wilson SH
通讯作者：
Wilson SH
DOI：
10.1016/j.bbagen.2006.05.012
发表时间：
2006-09-01
影响因子：
3
作者：
Arakaki, Naokatu;Nishihama, Takeshi;Higuti, Tomihiko
通讯作者：
Higuti, Tomihiko
影响因子：
11.4
作者：
Beattie, Thomas R.;Bell, Stephen D.
通讯作者：
Bell, Stephen D.
影响因子：
4.8
作者：
Bermudez, VP;MacNeill, SA;Hurwitz, J
通讯作者：
Hurwitz, J
影响因子：
14.9
作者：
Bacquin, Agathe;Pouvelle, Caroline;Kannouche, Patricia L.
通讯作者：
Kannouche, Patricia L.