Efficacy of ibuprofen-hydrocodone for the treatment of postoperative pain after periodontal surgery
Efficacy of ibuprofen-hydrocodone for the treatment of postoperative pain after periodontal surgery
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DOI：
10.1902/jop.2004.75.6.872
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发表时间：
2004-06-01
影响因子：
4.3
通讯作者：
Farooqi, OA
中科院分区：
文献类型：
--
作者：
Betancourt, JW;Kupp, LI;Farooqi, OA
背景：先前的研究表明，非甾体类抗炎药（NSAID）在控制牙周或口腔外科手术后的术后疼痛方面具有显着的益处。外周作用的非甾体抗炎药与中枢作用的阿片类药物的组合被发现更有效。本研究的目的是比较 400 mg 布洛芬与 5 mg 羟考酮的替代组合与单独使用 400 mg 布洛芬治疗牙周手术后疼痛的效果。 方法：本研究采用双盲交叉设计，患者作为自己的对照。 12 名患者在同一牙弓的不同象限接受了两次牙周手术，间隔至少两周。需要标准化的局部麻醉剂量以及每侧相似的手术范围和持续时间。患者按预定时间间隔接受四剂药物，并在术后前 12 小时内每 2 小时填写一次视觉模拟疼痛量表。结果：患者在视觉模拟疼痛量表上报告的总体疼痛为 1.55 (SE +/- 0.16)，满分为 10。与布洛芬与氢可酮组合相比，单独使用布洛芬报告的疼痛更多，为 1.81 (SE +/- 0.12)， 1.30（标准误差+/-0.16）。差异有统计学意义（P
Background: Previous studies have shown that non-steroidal anti-inflammatory drugs (NSAIDs) have significant benefits in the control of postoperative pain after periodontal or oral surgical procedures. The combination of a peripherally acting NSAID with a centrally acting opioid drug is found to be more effective. The purpose of this study was to compare an alternative combination of ibuprofen 400 mg with 5 mg of hydroxycodone to ibuprofen 400 mg used alone in the management of pain following periodontal surgery.Methods: This study used a double-masked cross-over design with the patients acting as their own controls. Twelve patients underwent two periodontal surgeries in different quadrants of the same dental arch at least 2 weeks apart. A standardized amount of local anesthetic and similar extent and duration of surgery for each side was required. The patients received four doses of medication at predetermined intervals and filled out a visual analog pain scale every 2 hours for the first 12 hours after surgery.Results: The overall pain reported by the patients on visual analog scale was 1.55 (SE +/- 0.16), out of a possible 10. More pain was reported with ibuprofen alone, 1.81 (SE +/- 0.12), compared to the ibuprofen with hydrocodone combination, 1.30 (SE +/- 0.16). The difference was statistically significant (P