Impregnation of silver nanoparticles into bacterial cellulose for antimicrobial wound dressing
Impregnation of silver nanoparticles into bacterial cellulose for antimicrobial wound dressing
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DOI：
10.1016/j.carbpol.2007.07.025
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发表时间：
2008-04-03
影响因子：
11.2
通讯作者：
Rujiravanit, Ratana
中科院分区：
文献类型：
--
作者：
Maneerung, Thawatchai;Tokura, Seiichi;Rujiravanit, Ratana
细菌纤维素由木醋杆菌（Acetobacter xylinum）（菌株TISTR 975）产生。细菌纤维素是用作伤口敷料的令人感兴趣的材料，因为它为伤口提供潮湿的环境，导致更好的伤口愈合。然而，细菌纤维素本身没有预防伤口感染的抗微生物活性。为了实现抗微生物活性，通过将细菌纤维素浸入硝酸银溶液中将银纳米颗粒浸渍到细菌纤维素中。然后用硼氢化钠将细菌纤维素内吸附的银离子（Ag+）还原为金属银纳米颗粒（Ago）。银纳米粒子在420 nm附近有光吸收带。当NaBH 4：AgNO 3的摩尔比减小时，光吸收带发生红移和展宽，表明银纳米颗粒的粒径和粒径分布增加，透射电子显微镜研究表明。X-射线衍射结果也证明了银纳米粒子的形成。冻干后的银纳米粒子浸渍细菌纤维素对革兰氏阴性大肠杆菌和革兰氏阳性金黄色葡萄球菌具有较强的抗菌活性。(c)2007爱思唯尔有限公司保留所有权利。
Bacterial cellulose was produced by Acetobacter xylinum (strain TISTR 975). Bacterial cellulose is an interesting material for using as a wound dressing since it provides moist environment to a wound resulting in a better wound healing. However, bacterial cellulose itself has no antimicrobial activity to prevent wound infection. To achieve antimicrobial activity, silver nanoparticles were impregnated into bacterial cellulose by immersing bacterial cellulose in silver nitrate solution. Sodium borohydride was then used to reduce the absorbed silver ion (Ag+) inside of bacterial cellulose to the metallic silver nanoparticles (Ago). Silver nanoparticles displayed the optical absorption band around 420 nm. The red-shift and broadening of the optical absorption band was observed when the mole ratio of NaBH4 to AgNO3 (NaBH4:AgNO3) was decreased, indicating the increase in particle size and particles size distribution of silver nanoparticles that was investigated by transmission electron microscope. The formation of silver nanoparticles was also evidenced by the X-ray diffraction. The freeze-dried silver nano particle-impregnated bacterial cellulose exhibited strong the antimicrobial activity against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). (c) 2007 Elsevier Ltd. All rights reserved.