Complementation analysis of male fertility among the segregation distorter chromosomes of Drosophila melanogaster.
Complementation analysis of male fertility among the segregation distorter chromosomes of Drosophila melanogaster.
复制标题
果蝇分离扭曲染色体中雄性生育力的互补分析。
作者：
D. Hartl
对11条不同SD染色体产生的55个SD(i)/SD(j)型基因型的繁殖力进行了测定。其中五种基因型是致命的，其余的生殖力呈生育和不育的模式，这高度暗示了宫颈内互补。导致男性生育能力的互补只是部分互补：大多数可育基因型的生育能力不到对照组的一半。我们分别对SD位点、Ac位点和2R中的修饰子这三个SD系统的组成部分进行了分析，结果表明互补是与SD位点相关的一种现象。根据这些观察结果，提出了与偏析畸变有关的分子事件的假设。该模型是基于这样的假设，即Sd位点产生一个多聚体分子，在精子发生过程中调节Ac（=Rsp）位点的活性。
The fecundities of 55 genotypes of the form SD(i)/SD(j) generated by 11 different SD chromosomes have been examined. Five of the genotypes are lethal The fecundities of the rest fall into a pattern of fertility and sterility that is highly suggestive of intracistronic complementation. The complementation leading to male fertility is only partial complementation: the fecundity of most fertile genotypes is less than half that of controls. The three components of the SD system, the Sd locus, the Ac locus, and the modifiers in 2R, were examined separately, and it appears that the complementation is a phenomenon associated with the Sd locus. A hypothesis of the molecular events involved in segregation distortion is formulated in the light of these observations. The model is based on the assumption that the Sd locus produces a multimeric molecule that regulates the activity of the Ac(=Rsp) locus during spermatogenesis.