EVENTCHARTS - VISUALIZING SURVIVAL AND OTHER TIMED-EVENTS DATA
EVENTCHARTS - VISUALIZING SURVIVAL AND OTHER TIMED-EVENTS DATA
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DOI：
10.2307/2684402
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发表时间：
1992-02-01
影响因子：
1.8
通讯作者：
GOLDMAN, AI
中科院分区：
文献类型：
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作者：
GOLDMAN, AI
生存和其他定时事件的Kaplan-Meier图是总结某些类型临床研究结果数据的一种非常有效的方法，但有关日期和事件之间相互作用的信息丢失了。提出了一种用于呈现此类数据的新模式，即事件图，该模式通过同时显示2-3种不同类型事件（包括删失和时间依赖性协变量事件）的时间来帮助从整体上查看研究。该图表有助于监测累积，并可用于“猜测”额外入组和/或随访所产生的信息量。事件图旨在补充而不是取代定量分析方法或传统生存图。骨髓移植和艾滋病研究的数据被用来说明的方法。提出了描述现代临床试验中研究的事件复杂性的概念和区分的术语，包括定时事件、损失和日期删失以及时间编织事件。
Kaplan-Meier graphs of survival and other timed events are an extremely effective way to summarize outcome data from some types of clinical studies, but information on dates and the interaction among events is lost. A new mode for presenting such data is proposed, an Eventchart, that aids in looking at the study as a whole by simultaneously displaying the timing of 2-3 different types of events, including censoring and time-dependent covariate events. The chart helps to monitor accrual and can be used to "guesstimate" the amount of information resulting from additional enrollment and/or follow-up. Eventcharts are designed to supplement, not replace, quantitative methods of analysis or conventional survival graphs. Data from bone marrow transplantation and AIDS studies are used to illustrate the method. Terminology is suggested for describing the concepts and distinguishing among the complex of events studied in modem clinical trials, including timed events, loss and date censoring, and time-braided events.