Cerebellar white matter abnormalities following primary blast injury in US military personnel.
Cerebellar white matter abnormalities following primary blast injury in US military personnel.
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DOI：
10.1371/journal.pone.0055823
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Brody DL
中科院分区：
文献类型：
--
作者：
Mac Donald C;Johnson A;Cooper D;Malone T;Sorrell J;Shimony J;Parsons M;Snyder A;Raichle M;Fang R;Flaherty S;Russell M;Brody DL
Little is known about the effects of blast exposure on the human brain in the absence of head impact. Clinical reports, experimental animal studies, and computational modeling of blast exposure have suggested effects on the cerebellum and brainstem. In US military personnel with isolated, primary blast-related ‘mild’ traumatic brain injury and no other known insult, we found diffusion tensor MRI abnormalities consistent with cerebellar white matter injury in 3 of 4 subjects. No abnormalities in other brain regions were detected. These findings add to the evidence supporting the hypothesis that primary blast exposure contributes to brain injury in the absence of head impact and that the cerebellum may be particularly vulnerable. However, the clinical effects of these abnormalities cannot be determined with certainty; none of the subjects had ataxia or other detected evidence of cerebellar dysfunction. The details of the blast events themselves cannot be disclosed at this time, thus additional animal and computational modeling will be required to dissect the mechanisms underlying primary blast-related traumatic brain injury. Furthermore, the effects of possible subconcussive impacts and other military-related exposures cannot be determined from the data presented. Thus many aspects of topic will require further investigation.
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影响因子：
17.1
作者：
Goldstein LE;Fisher AM;Tagge CA;Zhang XL;Velisek L;Sullivan JA;Upreti C;Kracht JM;Ericsson M;Wojnarowicz MW;Goletiani CJ;Maglakelidze GM;Casey N;Moncaster JA;Minaeva O;Moir RD;Nowinski CJ;Stern RA;Cantu RC;Geiling J;Blusztajn JK;Wolozin BL;Ikezu T;Stein TD;Budson AE;Kowall NW;Chargin D;Sharon A;Saman S;Hall GF;Moss WC;Cleveland RO;Tanzi RE;Stanton PK;McKee AC
通讯作者：
McKee AC
DOI：
10.1097/00005373-197403000-00001
发表时间：
1974-01-01
影响因子：
--
作者：
BAKER, SP;ONEILL, B;LONG, WB
通讯作者：
LONG, WB
影响因子：
5.7
作者：
Davenport, Nicholas D.;Lim, Kelvin O.;Sponheim, Scott R.
通讯作者：
Sponheim, Scott R.
影响因子：
4.2
作者：
Lu, Jia;Ng, Kian Chye;Ling, Eng-Ang
通讯作者：
Ling, Eng-Ang
影响因子：
3.8
作者：
Bass, Cameron R.;Panzer, Matthew B.;Capehart, Bruce
通讯作者：
Capehart, Bruce