Evoked potentials generated by noxious stimulation in the human infant brain
Evoked potentials generated by noxious stimulation in the human infant brain
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DOI：
10.1016/j.ejpain.2009.05.005
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发表时间：
2010-03-01
影响因子：
3.6
通讯作者：
Fitzgerald, Maria
中科院分区：
文献类型：
--
作者：
Slater, Rebeccah;Worley, Alan;Fitzgerald, Maria
虽然人类婴儿可以对有害刺激表现出独特的行为和生理脊髓和脑干反应，但尚不清楚新生儿的皮质神经元是否被有害刺激特异性激活。在这里，我们使用一种新颖的方法将脑电图记录时间锁定到临床所需的足跟矛，显示新生儿（月经后 35-39 周）存在明显的伤害性特异性潜力。可以在中央电极（Cz 和 CPz）的单次试验中观察到电势，并使用主成分分析，其特征是在刺激后约 560 ms 处出现阳性（N420-P560；P，正；N，负）。伤害性特异性电位的大小不依赖于睡眠状态，而早期电位 (N150-P260-N430) 依赖于睡眠状态，由有害和非有害刺激引起。这些结果提供了婴儿大脑中特定的伤害性诱发神经活动的第一个直接证据，并表明新生婴儿能够对疼痛体验进行感觉辨别。 (C) 2009 年欧洲联合会国际疼痛研究协会分会。由爱思唯尔有限公司出版。保留所有权利。
While human infants can display distinctive behavioural and physiological spinal cord and brainstem responses to noxious stimulation, it is not known whether cortical neurons are specifically activated by noxious stimuli in newborns. Here, using a novel approach to time-lock an EEG recording to a clinically required heel lance, we show the presence of a distinct nociceptive-specific potential in newborn infants (35-39 weeks postmenstrual age). The potential can be observed in single trials in the central electrodes (Cz and CPz) and using principal component analysis is characterised by a positivity that occurs at approximately 560 ms post-stimulus (N420-P560; P, positive; N, negative). The magnitude of the nociceptive-specific potential is not dependent on sleep state, whereas an earlier potential (N150-P260-N430), which is sleep-state dependent, is evoked by both noxious and non-noxious stimulation. These results provide the first direct evidence of specific noxious-evoked neural activity in the infant brain and suggest that newborn infants are capable of the sensory-discriminative aspects of pain experience. (C) 2009 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.