Influence of excess dietary copper on lipid composition of calf tissues.
Influence of excess dietary copper on lipid composition of calf tissues.
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DOI：
10.3168/jds.s0022-0302(89)79399-1
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发表时间：
1989-10
影响因子：
3.5
通讯作者：
K. Jenkins;J.K.G. Kramer
中科院分区：
文献类型：
--
作者：
K. Jenkins;J.K.G. Kramer
测定了小牛肝脏、心脏和骨骼肌的脂质组成，如受对照Cu（DM中10 ppm）、高Cu（1000 ppm）或高Cu加高Zn（1000 ppm）的牛奶添加剂的影响。高饮食铜增加所有的脂质类在肝脏中，一些在心脏中，并降低所有的脂质类，但在肌肉中的胆固醇。锌抑制了许多组织脂质类的变化，过量的铜。高铜摄入增加脂肪酸不饱和度（棕榈油酸，油酸，亚油酸）和减少硬脂酸的肝和心脏的磷脂酰胆碱和磷脂酰乙醇胺。过量的铜往往有相反的效果，在改变肝脏和肌肉中的脂肪酸浓度。各种去饱和酶和延长酶的活性估计在肝脏，心脏和肌肉中使用的脂肪酸前体的比例结合磷脂酰胆碱和磷脂酰乙醇胺的产品。高铜摄入量经常改变这些酶在所有三个组织中的活动，额外的高锌通常coregulating活动的方向相反，铜。
Lipid composition of calf liver, heart, and skeletal muscle was measured, as affected by control Cu (10 ppm in DM), high Cu (1000 ppm), or high Cu plus high Zn (1000 ppm) in milk replacer. High dietary Cu increased all lipid classes in liver, some in the heart, and decreased all lipid classes except cholesterol in muscle. Zinc inhibited many of the changes in tissue lipid classes by excess copper. High Cu intake increased fatty acid unsaturation (palmitoleic, oleic, linoleic acids) and decreased stearic acid in phosphatidylcholine and phosphatidylethanolamine of liver and heart. Excess Cu tended to have an opposite effect in changing fatty acid concentrations in liver and muscle. Activities of various desaturases and elongases were estimated in liver, heart, and muscle using ratios of fatty acid precursors to products in combined phosphatidylcholine and phosphatidylethanolamine. High Cu intake frequently altered activities of these enzymes in all three tissues with additional high Zn usually coregulating activity in the direction opposite to Cu.