Birth weight predicts response to vaccination in adults born in an urban slum in Lahore, Pakistan
Birth weight predicts response to vaccination in adults born in an urban slum in Lahore, Pakistan
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DOI：
10.1093/ajcn/80.2.453
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发表时间：
2004-08-01
影响因子：
7.1
通讯作者：
Hanson, LÅ
中科院分区：
文献类型：
--
作者：
Moore, SE;Jalil, F;Hanson, LÅ
背景：有大量证据表明，出生时身材矮小与日后对慢性疾病的易感性有关。还有证据表明，免疫功能的某些组成部分可能在生命早期就被编程了。然而，这一证据是有限的，需要确认。目的：我们调查了257名成年人的队列中出生时体型与疫苗接种反应之间的关系（平均年龄：29.4岁; 146名男性），1964- 1978年出生于巴基斯坦拉合尔的一个城市贫民窟。设计：每名受试者接种1剂伤寒Vi多糖疫苗和2剂狂犬病疫苗。结果：受试者的平均出生体重为3.24 kg，14%的受试者出生体重偏低，
Background: Substantial evidence exists linking small size at birth to later-life susceptibility to chronic disease. Evidence is also emerging that some components of immune function may be programmed in early life. However, this evidence is limited and requires confirmation.Objective: We investigated the association between size at birth and response to vaccination in a cohort of 257 adults (mean age: 29.4 y; 146 men) born in an urban slum in Lahore, Pakistan, during 1964-1978.Design: A single dose of Vi polysaccharide vaccine for Salmonella typhi and 2 doses of rabies vaccine were given to each subject. Antibody titers were measured in prevaccination serum samples (Vi) and in postvaccination samples (Vi and rabies).Results: The mean birth weight of the subjects was 3.24 kg; 14% of the subjects had low birth weights (