Pupil Dilation Progression Modulates Aberrant Social Cognition in Autism Spectrum Disorder
Pupil Dilation Progression Modulates Aberrant Social Cognition in Autism Spectrum Disorder
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DOI：
10.1002/aur.2178
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发表时间：
2019-07-25
期刊：
影响因子：
4.7
通讯作者：
Freitag, Christine M.
中科院分区：
文献类型：
--
作者：
Bast, Nico;Banaschewski, Tobias;Freitag, Christine M.
响应视觉刺激的瞳孔扩张（PD）的进展可能表明不同的内部过程。尚未对社会认知任务期间帕金森病的进展进行研究。在这里，我们描述了 n = 23 名患有自闭症谱系障碍 (ASD) 的青少年和 n = 24 名年龄、智商和性别匹配的神经典型对照 (NTC) 的社会认知评估 (MASC) 测试电影中的 PD 进展。 MASC 由 43 个描述人类社交互动的视频序列组成，每个视频序列后面都有一个有关角色心理状态的多项选择题。通过眼动追踪提取 PD 进展数据并控制注视行为。通过主成分分析对视频序列中的 PD 进展进行分段，揭示了三个连续的 PD 成分。与 NTC 相比，在 ASD 中观察到明显的 PD 进展，包括收缩幅度增加、扩张潜伏期延长以及与 PD 进展成分相关的扩张幅度增加。这些成分预测了社会认知表现。在 ASD 中，第一和第二 PD 成分与 MASC 行为表现呈正相关，但在 NTC 中呈负相关。这些 PD 成分可以解释为感觉知觉处理和注意力功能的指标。在自闭症谱系障碍中，异常的感官知觉处理和注意力功能可能导致社会认知能力下降。这需要通过结合各自的认知测试和概述的 PD 进展分析的额外研究来测试。蓝斑-去甲肾上腺素系统的阶段性活动被认为是共同的潜在机制。自闭症研究 2019。 (c) 2019 年作者。国际自闭症研究协会出版的自闭症研究，Wiley periodicals, Inc. 出版。 总结 在患有自闭症的青少年中，我们发现在观看人类互动场景时瞳孔扩张发生了变化。早期瞳孔扩张与对所显示的人类互动问题的正确答案数量呈正相关。我们的研究结果表明，异常的感觉处理和注意力功能可能导致自闭症患者社会认知的改变。
Progression of pupil dilation (PD) in response to visual stimuli may indicate distinct internal processes. No study has been performed on PD progression during a social cognition task. Here, we describe PD progression during the Movie for the Assessment of Social Cognition (MASC) test in n = 23 adolescents with Autism Spectrum Disorder (ASD) and n = 24 age, IQ and sex-matched neurotypical controls (NTC). The MASC consists of 43 video sequences depicting human social interactions, each followed by a multiple-choice question concerning characters' mental states. PD progression data were extracted by eye tracking and controlled for fixation behavior. Segmenting PD progression during video sequences by principal component analysis, three sequential PD components were unveiled. In ASD compared with NTC, a distinct PD progression was observed with increased constriction amplitude, increased dilation latency, and increased dilation amplitude that correlated with PD progression components. These components predicted social cognition performance. The first and second PD components correlated positively with MASC behavioral performance in ASD but negatively in NTC. These PD components may be interpreted as indicators of sensory-perceptual processing and attention function. In ASD, aberrant sensory-perceptual processing and attention function could contribute to attenuated social cognition performance. This needs to be tested by additional studies combining the respective cognitive tests and the outlined PD progression analysis. Phasic activity of the locus coeruleus-norepinephrine system is discussed as putatively shared underlying mechanism. Autism Res2019. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. Lay Summary In adolescents with autism, we found an altered pupil dilation during watching scenes of human interactions. Early pupil dilation correlated positively with the number of correct answers to questions about the shown human interactions. Our findings suggest that aberrant sensory processing and attention function may contribute to altered social cognition in autism.