HABITUATION OF THE BLINK REFLEX IN NORMALS AND SCHIZOPHRENIC-PATIENTS
HABITUATION OF THE BLINK REFLEX IN NORMALS AND SCHIZOPHRENIC-PATIENTS
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DOI：
10.1111/j.1469-8986.1982.tb02589.x
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发表时间：
1982-01-01
期刊：
影响因子：
3.7
通讯作者：
BRAFF, DL
中科院分区：
文献类型：
--
作者：
GEYER, MA;BRAFF, DL
本研究表明，精神分裂症患者对惊吓刺激的防御性反应的习惯性受损。通过计算机监测人类惊吓对 116 HB(A) 音调（40 毫秒，1000 赫兹）的眨眼反射成分，并将其与自愿眨眼区分开来。在背景噪声水平为 70 dB(A) 的情况下，以平均 15 秒的不同间隔发出 121 种音调。所有接受测试的 3 组（25 名假定正常人、20 名精神病患者对照组和 22 名精神分裂症患者）对第一组刺激都表现出相似的反应。虽然正常人和患者对照表现出.apprx。整个试验中反应幅度下降了 70%，精神分裂症患者的习惯下降 < 50%。一个意外的发现是，正常人和对照的潜伏期到峰值与试验次数和响应幅度均非单调相关。当重复相同的刺激时，延迟先增加然后减少。与振幅习惯一样，这种现象在精神分裂症患者中也被延迟。精神分裂症患者对外感受刺激有异常的防御反应习惯。讨论了精神分裂症异常习惯和症状形成之间可能的联系。
The present study demonstrates an impairment of habituation in schizophrenic patients on a measure of defensive responding to startling stimuli. The blink reflex component of human startle in response to 116 HB(A) tones (40 ms, 1000 Hz) was monitored and distinguished from voluntary eyeblinks by a computer. With a background noise level of 70 dB(A), 121 tones were given at varied intervals averaging 15 s. All 3 groups tested, 25 presumed normals, 20 psychiatric patient controls and 22 schizophrenic patients, exhibited similar responses to the 1st several stimuli. While normals and patient controls exhibited .apprx. 70% decrements in response amplitudes across trials, schizophrenic patients habituated by < 50%. An unexpected finding was that the latency-to-peak values for normals and controls were non-monotonically related to both trial number and response amplitudes. Latencies first increased and then decreased as the same stimulus was repeated. As with amplitude habituation, this phenomenon was also delayed in the schizophrenic patients. Schizophrenic patients have abnormal habituation of defensive responses to exteroceptive stimuli. Possible links between abnormal habituation and symptom formation in schizophrenia are discussed.