Skin Langerhans cells play an essential role in the defense against HSV-1 infection
Skin Langerhans cells play an essential role in the defense against HSV-1 infection
复制标题
皮肤朗格汉斯细胞在防御 HSV-1 感染中发挥重要作用
作者：
E. Sprecher;Y. Becker
本文研究了郎格罕细胞（LC）在HSV-1感染小鼠皮肤中的作用。LC作为非常有效的抗原呈递细胞发挥功能，并代表体内最外周的免疫细胞成分。足垫途径用于研究LC对HSV-1致病性和非致病性菌株感染的反应。在感染了致病性HSV-1菌株后，足垫皮肤中的LC数量增加。通过用10%盐水和擦伤处理从皮肤中去除LC导致HSV-1毒力增强，非致病性病毒变得具有高致病性。在愈合过程中，皮肤中LC的逐步恢复伴随着对HSV-1感染的抵抗力的逐渐增加。
SummaryThe role of the Langerhans cells (LC) during HSV-1 infection in murine skin was examined. LC function as very potent antigen-presenting cells and represent the most peripheral immune cellular elements in the body. The footpad route was used to study the response of LC to infection with a pathogenic and non-pathogenic strain of HSV-1. Following infection with a pathogenic HSV-1 strain, there was an increase in the number of LC in the footpad skin. Depletion of LC from the skin by treatment with 10 per cent aqueous saline and abrasion led to the enhancement of HSV-1 virulence and the nonpathogenic virus became highly pathogenic. Progressive recovery of LC in the skin during the healing process was accompanied by a gradual increase in resistance to HSV-1 infection.
朗格汉斯细胞生物学：通过实验分析从人体皮肤中去除朗格汉斯细胞。
DOI：
10.1111/1523-1747.ep12261453
发表时间：
1984
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Krueger,GG;Emam,M
通讯作者：
Emam,M