Risk factors for pterygium recurrence after limbal-conjunctival autografting: a retrospective, single-centre investigation
Risk factors for pterygium recurrence after limbal-conjunctival autografting: a retrospective, single-centre investigation
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DOI：
10.1007/s10384-018-0582-9
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发表时间：
2018-05-01
影响因子：
2.4
通讯作者：
Heidarpanah, Maryam
中科院分区：
文献类型：
--
作者：
Aidenloo, Naser Samadi;Motarjemizadeh, Qader;Heidarpanah, Maryam
旨在确定与自体角膜缘结膜移植翼状胬肉切除术后翼状胬肉复发相关的危险因素。回顾性、观察性病例系列。当前的研究包括 310 名接受自体角膜缘结膜移植手术切除翼状胬肉的患者。 2006 年至 2011 年间，所有手术均由同一家医院的同一位外科医生完成。收集术前和术后患者数据。患者被传唤进行后续检查。经过至少 12 个月随访的手术均纳入最终分析。采用Cox比例风险线性分析确定翼状胬肉复发的潜在危险因素，并采用Kaplan-Meier法评估无复发生存时间。平均随访时间20.1±8.6个月（范围12-37个月），总复发率为5.2%。根据 Kaplan-Meier 评估，整个人群的预计复发时间为 34.2 +/- 0.5 个月（95% 置信区间为 33.3-35.0 个月）。多变量分析显示，年龄< 45岁（RR = 3.582，95% CI 1.984-13.044，P = 0.047），复发型翼状胬肉（RR = 4.856，95% CI 1.794-13.142，P = 0.002），翼状胬肉垂直尺寸> 6.7 mm（RR = 2.529, 95% CI 1.053-6.075，P = 0.038）与复发风险增加显着相关。我们的研究结果表明，年轻、翼状胬肉复发类型和较大翼状胬肉组织是手术切除后翼状胬肉复发的危险因素。因此，建议尽早切除翼状胬肉，以降低复发率。
To determine the risk factors related to recurrence of pterygium after pterygium excision with limbal-conjunctival autograft.Retrospective, observational case series.The current study included 310 patients who underwent surgical removal of pterygium using limbal-conjunctival autografting. All surgery was performed by the same surgeon at a single Hospital from 2006 to 2011. Preoperative and postoperative patient data were collected. The patients were summoned to follow-up examinations. Procedures with at least 12 months of follow-up were included in the final analysis. Potential risk factors for pterygium recurrence were determined by Cox proportional-hazard linear analysis and recurrence-free survival time was evaluated using Kaplan-Meier method.The overall recurrence rate was 5.2% during an average follow-up time of 20.1 +/- 8.6 months (range, 12-37 months). According to Kaplan-Meier evaluation, the estimated time to recurrence was 34.2 +/- 0.5 months (95% confidence interval 33.3-35.0 months) for the whole population. Multivariate analysis showed that age < 45 years old (RR = 3.582, 95% CI 1.984-13.044, P = 0.047), recurrent type of pterygia (RR = 4.856, 95% CI 1.794-13.142, P = 0.002), and vertical size of pterygium > 6.7 mm (RR = 2.529, 95% CI 1.053-6.075, P = 0.038) were significantly associated with increased risk of recurrence.Our findings suggest that young age, recurrent type of pterygia, and larger pterygial tissue are risk factors for pterygium recurrence after surgical excision. Hence, early excision of pterygium is recommended to decrease the recurrence rate.