Effect of smoking on serum RANKL and OPG in sex, age and clinically matched supportive-therapy periodontitis patients
Effect of smoking on serum RANKL and OPG in sex, age and clinically matched supportive-therapy periodontitis patients
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DOI：
10.1111/j.1600-051x.2007.01048.x
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发表时间：
2007-04-01
影响因子：
6.7
通讯作者：
Macpherson, Lorna M. D.
中科院分区：
文献类型：
--
作者：
Lappin, David F.;Sherrabeh, Sakhr;Macpherson, Lorna M. D.
方法：通过酶联免疫吸附试验（ELISA）测定牙周病水平几乎相同的年龄和性别匹配的吸烟者和非吸烟者中核因子κB配体受体激活剂（RANKL）和骨保护素（OPG）的血清浓度。我们确保35名吸烟者的性别、年龄和临床情况与一组35名非吸烟者相匹配（通过可替宁确认）结果：吸烟者的 RANKL 和 OPG 血清浓度往往低于不吸烟者。虽然 RANKL 没有观察到统计学上的显着差异，但 OPG 的中位血清浓度（吸烟者 23.76 pM，非吸烟者 59.28 pM）以及 RANKL 和 OPG 血清浓度的比率存在显着差异。吸烟者的OPG浓度与烟草消费量也呈统计学上显着的负相关。结论：吸烟者相关性牙周炎患者的骨质流失可能部分是由于OPG产生的抑制所致。
Methods: The serum concentrations of receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) in age- and sex-matched groups of smokers and non-smokers with almost identical levels of periodontal disease were determined by an enzyme-linked immunosorbent assay (ELISA).We ensured that the 35 smokers were gender, age and clinically matched with a group of 35 non-smokers (confirmed by cotinine immunoassay) from the same population of maintained patients with susceptibility to periodontitis.Results: Cigarette smoker patients tended to have lower serum concentrations of RANKL and OPG than non-smoker patients. While no statistically significant difference was observed for RANKL, there were significant differences in the median serum concentration of OPG (smokers 23.76 pM, non-smokers 59.28 pM) and the ratio of serum concentrations of RANKL and OPG. Concentrations of OPG in the smoker patients also had a statistically significant negative correlation with tobacco consumption.Conclusion: Bone loss in smoker-related periodontitis patients may be partially explained by suppression of OPG production.