Interictal and postictal circadian and ultradian luteinizing hormone secretion in men with temporal lobe epilepsy.
Interictal and postictal circadian and ultradian luteinizing hormone secretion in men with temporal lobe epilepsy.
复制标题
颞叶癫痫男性发作间期和发作后的昼夜节律和超昼夜黄体生成素分泌。
DOI：
10.1111/j.1528-1167.2006.00617.x
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发表时间：
2006
期刊：
影响因子：
5.6
通讯作者：
Evans,WilliamS
中科院分区：
文献类型：
--
作者：
Quigg,Mark;Kiely,JamesM;Johnson,MichaelL;Straume,Martin;Bertram,EdwardH;Evans,WilliamS
目的：颞叶癫痫（TLE）下丘脑对生殖轴的调节，以黄体生成素（LH）的超昼夜脉冲式分泌为代表，已被证明在发作间期和发作后发生改变。我们的目的是确定癫痫或癫痫发作是否破坏LH的正常昼夜节律波动以及LH的超昼夜爆发的昼夜节律组织。方法：我们在两个24小时的块期间的10名男性TLE的LH分泌的特点：发作间期和发作后发作期癫痫发作。结果：对照组LH平均峰值出现在0.0400，发作间期明显延迟0.5h，且呈随机分布，与正常对照组比较，差异有统计学意义（P < 0.05）。爆发振幅显着不同的相位之间的控制，与0101和0700之间的最大振幅和1301和1900之间的最小。发作间期或发作后时期无相位差。爆发频率弱，但显着是最慢的0101和0700之间的控制，但没有显着差异，无论是发作间期或发作后时期的阶段。发作后LH爆发频率，但不是振幅，立即posttically.Conclusion显着降低：LH的脉冲式分泌在TLE是异常的，无论是在昼夜节律以及超昼夜域。发作间期效应主要包括LH爆发振幅的昼夜节律波动的损失，而发作后效应包括改变爆发时间。神经内分泌信号的日常模式改变可能是TLE中其他稳态紊乱的基础。
Purpose:Hypothalamic regulation of the reproductive axis in temporal lobe epilepsy (TLE), represented by the ultradian pulsatile secretion of luteinizing hormone (LH), has been shown to be altered interictally and postictally. Our objective is to determine if epilepsy or seizures disrupt normal circadian fluctuations of LH as well as circadian organization of ultradian bursts of LH.Methods:We characterized LH secretion in 10 men with TLE during two 24‐h blocks: an interictal epoch and a postictal epoch initiated by a seizure. Serum LH was measured every 10 min and characterized by circadian and ultradian patterns with cosinor and deconvolution analysis.Results:Mean peak serum concentrations of LH occurred at ∼0400 in controls, were significantly delayed ∼5 h interictally, and were randomly distributed postictally. Burst amplitudes differed significantly by phase among controls, with the largest amplitudes between 0101 and 0700 and the smallest between 1301 and 1900. No phase differences were present in interictal or postictal epochs. Burst frequency weakly but significantly was slowest between 0101 and 0700 in controls, but did not differ significantly by phase in either interictal or postictal epochs. Postictal LH burst frequencies, but not amplitudes, were significantly decreased immediately postictally.Conclusion:The pulsatile secretion of LH in TLE is abnormal both in the circadian as well as the ultradian domain. Interictal effects consist mainly in loss of circadian fluctuations in LH burst amplitude, whereas postictal effects consist of altered burst timing. Altered daily patterns of neuroendocrine signals may underlie other disorders of homeostasis in TLE.