Roles of the T antigens in transformation by SV40.
Roles of the T antigens in transformation by SV40.
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T 抗原在 SV40 转化中的作用。
DOI：
10.1101/sqb.1980.044.01.036
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
J. Avila
中科院分区：
文献类型：
--
作者：
R. G. Martin;V. Setlow;A. Chepelinsky;R. Seif;A. Lewis;C. Scher;C. Stiles;J. Avila
1966年，Todaro和Green（1966，1967）证明，如果在吸附病毒后立即以低细胞密度重新铺板，则SV40对静息细胞的转化效率可以大大提高。 This result implied that the virus was inefficient in its ability to establish the transformed phenotype in resting cells. Data now suggest that the initial events leading to stable integration of SV40 into the host genome can be divided into three steps.
In 1966, Todaro and Green (1966, 1967) demonstrated that the efficiency of transformation of resting cells by SV40 could be greatly enhanced if the cells were replated at low cell densities immediately after adsorption of the virus. This result implied that the virus was inefficient in its ability to establish the transformed phenotype in resting cells. Data now suggest that the initial events leading to stable integration of SV40 into the host genome can be divided into three steps.