Prevalence and Risk Factors of Reduced Bone Mineral Density in Systemic Lupus Erythematosus Patients: A Meta-Analysis
Prevalence and Risk Factors of Reduced Bone Mineral Density in Systemic Lupus Erythematosus Patients: A Meta-Analysis
复制标题
系统性红斑狼疮患者骨矿物质密度降低的患病率和危险因素：荟萃分析
DOI：
10.1155/2019/3731648
复制
发表时间：
2019-01-01
影响因子：
--
通讯作者：
Zeng, Rui
中科院分区：
文献类型：
--
作者：
Xia, Jumei;Luo, Ran;Zeng, Rui
背景：我们的目的是进行一项荟萃分析，探讨系统性红斑狼疮（SLE）患者骨矿物质密度（BMD）降低的频率和危险因素，并从已发表的研究中获得证据。方法基于EMBASE、Web of Science、PubMed和科克伦图书馆数据库进行全面文献检索，截止日期为2017年3月5日。符合条件的研究报告了SLE患者BMD降低的任何患病率。提取了所有与BMD降低相关的风险因素及其比值比或风险比。结果共纳入71篇文献，共33527例SLE患者。45%、38%和13%的SLE患者存在任何部位的低BMD、骨量减少和骨质疏松。随着年龄的增长，骨质疏松症患病率逐渐增加，低骨密度和骨量减少的患病率与年龄呈U型关系，腰椎骨质疏松症患病率较高。年龄、病程、药物使用和许多其他因素被确定为BMD降低的预测因素。结论SLE患者普遍存在低BMD、骨质疏松和骨量减少。骨密度降低的危险因素是多方面的。
Background We aimed to conduct a meta-analysis concerning the frequency and risk factors of reduced bone mineral density (BMD) in systemic lupus erythematosus (SLE) with evidence from published studies. Methods A comprehensive literature search was conducted based on the EMBASE, Web of Science, PubMed, and Cochrane Library databases up to March 5th, 2017. Eligible studies reported any prevalence of reduced BMD in SLE patients. All risk factors with odds ratios or risk ratios associated with reduced BMD were extracted. Results 71 reports with 33527 SLE patients were included. Low BMD, osteopenia, and osteoporosis at any site were presented, respectively, in 45%, 38%, and 13% of the SLE patients. The prevalence of osteoporosis increased with the advancing of age, while U-shaped associations between age and the prevalence of low BMD and osteopenia were found. Lumbar spine was indicated to have higher prevalence of osteoporosis. Age, disease duration, drugs use, and many other factors were identified as predictors of reduced BMD. Conclusion Low BMD, osteoporosis, and osteopenia appeared to be prevalent in patients with SLE. Risk factors of reduced BMD were various.