Prevalence and prognosis of Brugada electrocardiogram patterns in an elderly Han Chinese population: a nation-wide community-based study (HALST cohort)
Prevalence and prognosis of Brugada electrocardiogram patterns in an elderly Han Chinese population: a nation-wide community-based study (HALST cohort)
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DOI：
10.1093/europace/euv141
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发表时间：
2015-10-01
期刊：
影响因子：
6.1
通讯作者：
Hsiung, Chao Agnes
中科院分区：
文献类型：
--
作者：
Juang, Jyh-Ming Jimmy;Chen, Ching-Yu Julius;Hsiung, Chao Agnes
目的Brugada模式在世界范围内的确切流行情况尚不清楚，特别是在55岁及以上的成年人中。方法和结果本研究是台湾健康老龄化纵向研究(HALST)的一部分。本研究采用分层随机抽样的方法，从台湾七个社区为基础的地区招募社区居民为研究对象。所有登记的受试者每年都会接受随访，死亡原因被记录在公民死亡记录中。共有5214名受试者(男/女：2530/2684)，平均年龄69+/-8岁。Brugada心电图型总患病率为3.32%。与世界范围内Brugada心电图的平均患病率相比，Halst队列中自发的1型Brugada心电图的患病率相似(0.077比0.07%)，而2型和3型的综合患病率高出10倍(3.24vs.0.28%)，甚至研究对象的平均年龄(69+/-8比35+/-8，P<；0.001)。有Brugada心电图型者与无Brugada心电图型者4年随访期间的全因死亡率及心脏死亡率差异无统计学意义(对数等级检验，P值分别为0.21、0.32)。结论台湾地区55岁及以上成人Brugada心电图型者的患病率高于全球平均患病率，但与死亡率增加无关。
Aims The exact world-wide prevalence of Brugada electrocardiogram (ECG) pattern is still unclear, especially in adults aged 55 years and older.Methods and results The study was conducted as part of the Healthy Aging Longitudinal Study in Taiwan (HALST). Using a stratified random sampled method, a sample of community-dwelling subjects was recruited from seven community-based regions across Taiwan. All enrolled subjects were follow-up annually and cause of death was documented by citizen death records. A total of 5214 subjects were enrolled (male/female: 2530/2684) with a mean age of 69 +/- 8 years. The overall prevalence of Brugada ECG patternswas 3.32%. Four subjects carried spontaneous Type 1 Brugada ECG pattern, 68 carried Type 2, and 101 carried Type 3. Compared with the world-wide average prevalence of Brugada ECG patterns, the prevalence of spontaneous Type 1 Brugada ECG pattern in subjects from the HALST cohort was similar (0.077 vs. 0.07%) and the combined prevalence of Types 2 and 3 Brugada ECG pattern was 10 times higher (3.24 vs. 0.28%) even the mean age of study subjects was significantly higher (69 +/- 8 vs. 35 +/- 8, P< 0.001). However, all-cause mortality and cardiac mortality rates were not significantly different between subjects with and without Brugada ECG patterns during the 4-year follow-up (log-rank test, P = 0.21, 0.32, respectively).Conclusion The prevalence of Brugada ECG pattern in adults aged 55 years and older in Taiwan was higher than the average worldwide prevalence but was not associated with increased mortality.