Prospective memory in HIV infection: Is "remembering to remember" a unique predictor of self-reported medication management?
Prospective memory in HIV infection: Is "remembering to remember" a unique predictor of self-reported medication management?
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DOI：
10.1016/j.acn.2007.12.006
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发表时间：
2008-05-01
影响因子：
2.6
通讯作者：
Atkinson, J. Hampton
中科院分区：
文献类型：
--
作者：
Woods, Steven Paul;Moran, Lisa M.;Atkinson, J. Hampton
最佳地坚持抗逆转录病毒药物治疗对于有效长期管理艾滋病毒感染至关重要。虽然前瞻性记忆（ProM;即，尽管HIV相关的ProM损伤（“记住要记住”）在药物依从性方面长期以来一直被理论化为起重要作用，但没有先前的研究评估HIV相关的ProM损伤是否在这方面具有独特的预测价值。这项研究的结果表明，在87名目前处方抗逆转录病毒药物的HIV感染者中，ProM损伤和自我报告的药物管理之间存在强有力的关联。具体而言，更频繁的ProM投诉和性能缺陷的实验室和半自然ProM任务都独立相关的自我报告的药物管理较差。一系列的分层回归分析显示，艾滋病毒相关的ProM损害占了显着的方差在自我报告的药物管理超出了其他因素的解释，已知的预测不遵守，包括情绪障碍，心理社会变量，环境结构，和赤字的传统电池的神经心理测试。总体而言，这些研究结果支持的假设，ProM捕捉到一个独特的，在很大程度上未开发的认知方面，是密切相关的最佳药物依从性。由ProM的概念模型和特定目标药物依从性告知的个体化补救策略的潜在益处值得进一步探索。(C)2008年美国国家神经心理学学会。由爱思唯尔有限公司出版。保留所有权利。
Optimal adherence to antiretroviral medications is critical to the effective long-term management of HIV infection. Although prospective memory (ProM; i.e., "remembering to remember") has long been theorized to play an important role in medication adherence, no prior studies have evaluated whether HIV-associated ProM impairment possesses unique predictive value in this regard. Results from this study demonstrate a robust association between ProM impairment and self-reported medication management in 87 HIV-infected persons currently prescribed antiretroviral medications. Specifically, more frequent ProM complaints and performance deficits on both laboratory and semi-naturalistic ProM tasks were all independently related to poorer self-reported medication management. A series of hierarchical regression analyses revealed that HIV-associated ProM impairment accounted for a significant amount of variance in self-reported medication management beyond that which was explained by other factors known to predict nonadherence, including mood disorders, psychosocial variables, environmental structure, and deficits on a traditional battery of neuropsychological tests. Overall, these findings support the hypothesis that ProM captures a unique and largely untapped aspect of cognition that is germane to optimal medication adherence. The potential benefits of individualized remediation strategies that are informed by conceptual models of ProM and specifically target medication adherence warrant further exploration. (C) 2008 National Academy of Neuropsychology. Published by Elsevier Ltd. All rights reserved.