Monosodium glutamate (MSG): A villain and promoter of liver inflammation and dysplasia
Monosodium glutamate (MSG): A villain and promoter of liver inflammation and dysplasia
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DOI：
10.1016/j.jaut.2007.11.016
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发表时间：
2008-02-01
影响因子：
12.8
通讯作者：
Gershwin, M. Eric
中科院分区：
文献类型：
--
作者：
Nakanishi, Yuko;Tsuneyama, Koichi;Gershwin, M. Eric
慢性炎症是包括自身免疫性疾病在内的各种疾病途径的共同主题。非酒精性脂肪性肝炎(NASH)很好地说明了慢性炎症的途径，由于其在西方化世界中的患病率不断上升，并与生活方式因素，特别是饮食因素直接相关，因此引起了严重关注。重要的是，NASH可能最终导致肝细胞癌的发生。我们之前曾报道，在ICR小鼠中注射谷氨酸钠(MSG)会导致严重的炎症、中心性肥胖和2型糖尿病。为了直接解决味精对炎症的长期后果，我们对注射了味精的小鼠进行了一系列分析，并特别关注肝脏病理。在6个月和12个月大时，所有服用味精的小鼠分别发展为NAFLD和NASH样组织学。特别是，12个月大的小鼠脂肪性肝炎几乎无法与人类NASH区分开来。此外，在一些病例中，在纤维化的肝实质内发现了发育不良的结节状病变。我们认为，对小鼠进行味精治疗会导致肥胖和糖尿病，并伴有脂肪变性和脂肪性肝炎，类似于人类NAFLD和NASH，具有肿瘤前病变。鉴于饮食中味精的广泛使用，这些结果具有相当重要的意义，我们建议重新检查味精的安全性，并有可能将其从食物链中撤出。(C)2007爱思唯尔有限公司。保留所有权利。
Chronic inflammation is a common theme in a variety of disease pathways, including autoimmune diseases. The pathways of chronic inflammation are well illustrated by nonalcoholic steatohepatitis (NASH), which is of a serious concern due to its increasing prevalence in the westernized world and its direct correlation with lifestyle factors, particularly diet. Importantly, NASH may ultimately lead to the development of hepatocellular carcinoma. We previously reported that injection of monosodium glutamate (MSG) in ICR mice leads to the development of significant inflammation, central obesity, and type 2 diabetes. To directly address the long-term consequences of MSG on inflammation, we have performed serial analysis of MSG-injected mice and focused in particular on liver pathology. By 6 and 12 months of age, all MSG-treated mice developed NAFLD and NASH-like histology, respectively. In particular, the murine steatohepatitis at 12 months was virtually undistinguishable from human NASH. Further, dysplastic nodular lesions were detected in some cases within the fibrotic liver parenchyma. We submit that MSG treatment of mice induces obesity and diabetes with steatosis and steatohepatitis resembling human NAFLD and NASH with pre-neoplastic lesions. These results take on considerable significance in light of the widespread usage of dietary MSG and we suggest that MSG should have its safety profile re-examined and be potentially withdrawn from the food chain. (C) 2007 Elsevier Ltd. All rights reserved.