Growing burden of sepsis-related mortality in northeastern Italy: a multiple causes of death analysis.
Growing burden of sepsis-related mortality in northeastern Italy: a multiple causes of death analysis.
复制标题
意大利东北部败血症相关死亡率的负担越来越大：死亡分析的多重原因。
DOI：
10.1186/s12879-016-1664-2
复制
发表时间：
2016-07-13
影响因子：
3.7
通讯作者：
Pellizzer G
中科院分区：
文献类型：
--
作者：
Fedeli U;Piccinni P;Schievano E;Saugo M;Pellizzer G
关于败血症死亡率的基于人群的数据很少。该研究的目的是估计败血症相关的死亡率和评估相关的合并症。从威尼托大区（意大利东北部）的多种死因数据（MCOD）中检索了2008-2013年期间死亡证明中提及的所有败血症死亡。在这些死亡中，调查了常见慢性合并症的发生率，以及潜在死亡原因（UCOD）的分布，即从证明中提到的所有病症中选择的单一疾病，通常列在死亡率统计数据中。对于选择作为UCOD的败血症，以及在证明中任何地方提到的败血症，计算年龄标准化死亡率。总共追踪了16906例败血症相关死亡。在所有区域死亡中，败血症占6.3%，从2008年的4.9%上升到2013年的7.7%。2008年败血症占总死亡人数的0.6%，2013年为1.6%。所有败血症相关死亡的年龄标准化死亡率增加了45%，作为UCOD的败血症死亡率增加了140%。脓毒症常伴有慢性合并症，尤其是肿瘤、糖尿病、循环系统疾病和痴呆。呼吸道和腹腔感染是最常见的相关感染部位。MCOD分析提供了脓毒症相关死亡率负担的估计。MCOD数据表明，认证医生对败血症的重视程度越来越高，但死亡率也在实际上升，从而证实了其他一些国家通过对出院记录的分析报告的趋势。
Few population-based data are available on mortality due to sepsis. The aim of the study was to estimate sepsis-related mortality rates and to assess the associated comorbidities. From multiple causes of death data (MCOD) of the Veneto Region (northeastern Italy), all deaths with sepsis mentioned anywhere in the death certificate were retrieved for the period 2008–2013. Among these deaths the prevalence of common chronic comorbidities was investigated, as well as the distribution of the underlying cause of death (UCOD), the single disease selected from all condition mentioned in the certificate and usually tabulated in mortality statistics. Age-standardized mortality rates were computed for sepsis selected as the UCOD, and for sepsis mentioned anywhere in the certificate. Overall 16,906 sepsis-related deaths were tracked. Sepsis was mentioned in 6.3 % of all regional deaths, increasing from 4.9 in 2008 to 7.7 % in 2013. Sepsis was the UCOD in 0.6 % of total deaths in 2008, and in 1.6 % in 2013. Age-standardized mortality rates increased by 45 % for all sepsis-related deaths, and by 140 % for sepsis as the UCOD. Sepsis was often reported in the presence of chronic comorbidities, especially neoplasms, diabetes, circulatory diseases, and dementia. Respiratory tract and intra-abdominal infections were the most frequently associated sites of infection. MCOD analyses provide an estimate of the burden of sepsis-related mortality. MCOD data suggest an increasing importance attributed to sepsis by certifying physicians, but also a real increase in mortality rates, thus confirming trends reported in some other countries by analyses of hospital discharge records.