SECRETION OF DOPAMINE INTO HYPOPHYSEAL PORTAL BLOOD BY RATS BEARING PROLACTIN-SECRETING TUMORS OR ECTOPIC PITUITARY-GLANDS
SECRETION OF DOPAMINE INTO HYPOPHYSEAL PORTAL BLOOD BY RATS BEARING PROLACTIN-SECRETING TUMORS OR ECTOPIC PITUITARY-GLANDS
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DOI：
10.1210/endo-105-3-636
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发表时间：
1979-01-01
期刊：
影响因子：
4.8
通讯作者：
PORTER, JC
中科院分区：
文献类型：
--
作者：
CRAMER, OM;PARKER, CR;PORTER, JC
从周期性不动情大鼠和非周期性不动情大鼠的垂体门静脉血浆中定量测定了由于PRL [催乳素]分泌垂体外植体或PRL分泌垂体肿瘤引起的高催乳素血症中的儿茶酚胺。在携带PRL分泌性肿瘤的大鼠中，PRL的血浆浓度为4450 ± 0.05。938 ng/ml（平均值±. SE），而在周期性间情动物中，血浆PRL水平为16 ± 0.5mg/kg。2.2 ng/ml。荷瘤大鼠垂体门脉血浆中多巴胺的浓度（2.0 ± 0.01）μ mol/L。0.3 ng/ml）显著高于（P <0.05）间情期大鼠（1.1 ± 0.01）。0.2 ng/ml）。垂体前叶催乳素含量为18 ± 0.5mg/kg。1.5在周期性间情动物中为9 μ g，在周期性间情动物中为9 ± 0 μ g。0.8. μ g。荷瘤动物的肾上腺重得多（155. ±. 14 mg）高于周期性间情大鼠（58 ± 14 mg）。1.2 mg）。荷瘤肾上腺切除大鼠门脉血浆中多巴胺浓度为2.0 ± 1.0mg/kg。0.5 ng/ml，与荷瘤完整动物门静脉血浆中的浓度相似。在肾被膜下保持4个垂体前叶外植体的大鼠中，PRL的动脉血浆浓度为178 ± 100 μ g/ml。20 ng/ml。垂体催乳素含量为11.0 ± 0.01。1.6在周期性间情动物中（19 ± 0.01），其显著低于（P <0.01）。1.9μ g）。周期性间情大鼠门脉血浆中多巴胺浓度为1.3 ± 1.5。0.23 ng/ml，为1.3 ±。0.36在异位垂体腺大鼠中，肿瘤分泌的物质，可能是PRL和/或ACTH样物质，显然可以导致下丘脑分泌多巴胺增加。
Catecholamines were quantified in hypophyseal portal plasma obtained from cycling diestrous rats and from noncycling diestrous rats with hyperprolactinemia due to PRL[prolactin]-secreting pituitary explants or a PRL-secreting pituitary tumor. In rats bearing PRL-secreting tumors, the plasma concentration of PRL was 4450 .+-. 938 ng/ml (mean .+-. SE), whereas in cycling diestrous animals the plasma level of PRL was 16 .+-. 2.2 ng/ml. The concentration of dopamine in hypophysial portal plasma of tumor-bearing rats (2.0 .+-. 0.3 ng/ml) was significantly greater (P < 0.05) than that in diestrous rats (1.1 .+-. 0.2 ng/ml). The anterior pituitary content of PRL was 18 .+-. 1.5 .mu.g in cycling diestrous animals and 9 .+-. 0.8 .mu.g in tumor-bearing rats. The adrenals from tumor-bearing animals were much heavier (155 .+-. 14 mg) than those from cycling diestrous rats (58 .+-. 1.2 mg). The concentration of dopamine in portal plasma from tumor-bearing adrenalectomized rats was 2.0 .+-. 0.5 ng/ml, similar to that in portal plasma from tumor-bearing intact animals. The arterial plasma concentration of PRL in rats bearing 4 anterior pituitary explants maintained under the renal capsule was 178 .+-. 20 ng/ml. The pituitary content of PRL was 11 .+-. 1.6 .mu.g, which was significantly less (P < 0.01) than that in cycling diestrous animals (19 .+-. 1.9 .mu.g). The dopamine concentration in portal plasma from cycling diestrous rats was 1.3 .+-. 0.23 ng/ml and was 1.3 .+-. 0.36 ng/ml in the rats bearing ectopic pituitary glands. Agents secreted by the tumor, possibly PRL and/or an ACTH-like substance, apparently can lead to an increased secretion of dopamine by the hypothalamus.