Repression of c-myc transcription by blimp-1, an inducer of terminal B cell differentiation
Repression of c-myc transcription by blimp-1, an inducer of terminal B cell differentiation
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DOI：
10.1126/science.276.5312.596
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发表时间：
1997-04-25
期刊：
影响因子：
56.9
通讯作者：
Calame, K
中科院分区：
文献类型：
--
作者：
Lin, Y;Wong, KK;Calame, K
浆细胞是终末分化的B细胞，其c-myc的转录受到浆细胞瘤抑制因子的抑制。这个因子被确定为Blimp-1，以其诱导B细胞分化的能力而闻名。Blimp-1以结合位点依赖的方式抑制c-myc启动子活性。用白细胞介素-2 （IL-2）加IL-5治疗BCL1淋巴瘤细胞诱导Blimp-1，并引起随后c-Myc蛋白的下降。Blimp-1在abelson转化前体细胞中的异位表达可抑制内源性c-Myc并引起细胞凋亡；c-Myc的异位表达部分克服了blimp -1诱导的死亡。因此，抑制c-myc是Blimp-1程序的末端B细胞分化的一个组成部分。
Transcription of c-myc in plasma cells, which are terminally differentiated B cells, is repressed by plasmacytoma repressor factor. This factor was identified as Blimp-1, known for its ability to induce B cell differentiation. Blimp-1 repressed c-myc promoter activity in a binding site-dependent manner. Treatment of BCL1 lymphoma cells with interleukin-2 (IL-2) plus IL-5 induced Blimp-1 and caused a subsequent decline in c-Myc protein. Ectopic expression of Blimp-1 in Abelson-transformed precursor B cells repressed endogenous c-Myc and caused apoptosis; Blimp-1-induced death was partially overcome by ectopic expression of c-Myc. Thus, repression of c-myc is a component of the Blimp-1 program of terminal B cell differentiation.