CUTANEOUS MALIGNANT-MELANOMA AND EXPOSURE TO SUNLAMPS OR SUNBEDS - AN EORTC MULTICENTER CASE-CONTROL STUDY IN BELGIUM, FRANCE AND GERMANY
CUTANEOUS MALIGNANT-MELANOMA AND EXPOSURE TO SUNLAMPS OR SUNBEDS - AN EORTC MULTICENTER CASE-CONTROL STUDY IN BELGIUM, FRANCE AND GERMANY
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DOI：
10.1002/ijc.2910580610
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发表时间：
1994-09-15
影响因子：
6.4
通讯作者：
KLEEBERG, UR
中科院分区：
文献类型：
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作者：
AUTIER, P;DORE, JF;KLEEBERG, UR
研究目的是评估暴露于日光灯和日光浴床是否是皮肤恶性黑色素瘤（CMM）的危险因素。在德国、法国和比利时的20岁或以上自然无色素皮肤受试者中进行了一项1：1非匹配病例对照研究。从1991年1月1日起，共有420例连续诊断为CMM的患者来自医院登记册; 447例无皮肤癌病史的对照组在同一城市随机选择。在1980年之前开始暴露于日光灯或日光浴床与累积暴露至少10小时的CMM的粗略估计风险2.71（95%CI：1.06 - 7 - 78）相关。在调整了年龄、性别、头发颜色和每年在阳光明媚的度假胜地度假的平均周数后，这种风险为2.12（95%CI：0.84 - 5.37）。由于日光灯或日光浴床而经历皮肤灼伤的受试者，以及累积暴露至少10小时的受试者，显示出粗略估计的CMM风险为4.47（95%CI：1.45 - 13.7），对于那些暴露皮肤用于晒黑目的的受试者，该风险上升至8.97（95%CI：2.10 - 38.6）。与皮肤灼伤相关的风险在对宿主特征和娱乐性阳光暴露进行多次调整后仅略有改变。显然，日光灯和日光浴床都增加了CMM的风险，这似乎集中在对紫外线辐射源表现出危险行为的受试者身上。然而，尽管有理由相信高剂量的纯紫外线A辐射可能是危险的，但这项研究并没有牢固地确立这一点。大多数暴露于紫外线A晒黑设备开始于1980年后，因此，流行病学研究很难揭示任何增加的风险CMM开始于1980年后，因为暴露和发生黑色素瘤之间的潜伏期。公共卫生当局应该对迅速发展的在日光灯或日光浴床下晒黑的时尚采取谨慎的态度。(C)1994 Wiley-Liss，Inc.
The study objective was to assess whether exposure to sunlamps and sunbeds represents a risk factor for cutaneous malignant melanoma (CMM). A 1 -to- 1 unmatched case-control study was conducted among subjects 20 years old or more with naturally non-pigmented skin in Germany, France and Belgium. A total of 420 consecutive patients with CMM diagnosed from 1 January 1991 onward were derived from hospital registers; 447 controls with no history of skin cancer were chosen at random in the same municipality as the cases. Exposure to sunlamps or sunbeds starting before 1980 is associated with a crude estimated risk of CMM of 2.71 (95% CI: 1.06-7-78) for at least 10 hr of accumulated exposure. This risk is of 2.12 (95% CI: 0.84-5.37) after adjustment for age, sex, hair colour and average number of holiday weeks each year in sunny resorts. Subjects who experienced skin-burn due to sunlamps or sunbeds, and who had accumulated at least 10 hr of exposure, displayed a crude estimated CMM risk at 4.47 (95% CI: 1.45-13.7), which rose to 8.97 (95% CI: 2.10-38.6) for those who exposed their skin for tanning purposes. The risk associated with skin-burn is only marginally modified after multiple adjustments for host characteristics and recreational exposure to sunlight. Apparently, sunlamps and sunbeds share the increased risk of CMM, which seems to concentrate in subjects exhibiting hazardous behaviour towards ultraviolet radiation sources. However, although it is reasonable to believe that high doses of pure ultraviolet A radiation can be dangerous, this is not firmly established by this study. Most exposures to ultraviolet A tanning devices began after 1980; therefore, epidemiologic studies have difficulty in revealing any increase in risk of CMM starting after 1980 because of the latent period between exposure and occurrence of melanoma. Public health authorities should have a cautious approach towards the rapidly developing fashion of tanning under sunlamps or sunbeds. (C) 1994 Wiley-Liss, Inc.