Prevalence, Clearance, and Incidence of Anal Human Papillomavirus Infection in HIV-Infected Men: The HIPVIRG Cohort Study
Prevalence, Clearance, and Incidence of Anal Human Papillomavirus Infection in HIV-Infected Men: The HIPVIRG Cohort Study
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DOI：
10.1086/597207
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发表时间：
2009-04-01
影响因子：
6.4
通讯作者：
Coutlee, Francois
中科院分区：
文献类型：
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作者：
de Pokomandy, Alexandra;Rouleau, Danielle;Coutlee, Francois
背景。人类免疫缺陷病毒 (HIV) 血清阳性的男男性行为者 (MSM) 感染人乳头瘤病毒 (HPV) 的风险较高。进行这项研究是为了更好地了解肛门中特定型 HPV 感染的自然史。方法。在蒙特利尔的 HIV 血清阳性 MSM 中进行了一项队列研究，以调查肛门 HPV 感染的获得和消失。参与者每 6 个月接受一次随访，持续 3 年，了解风险行为、HIV 相关参数和 HPV 检测。结果。在 247 名参与者中，基线时 97.9% 的人检测到 HPV DNA（中位数为 5 种 HPV 类型）。最常见的类型是 HPV-16 (38.2%) 和 HPV-6 (35.3%)。流行的 HPV-16 感染的清除率最低（每 1000 人月有 12.2 次清除事件 [95% 置信区间 {CI}，8.5-17.7]），平均保留时间为 36 个月（95% CI，32.7-38.8）。 HPV-16（每 1000 人月有 10.8 个新病例 [95% CI，8.0-14.7]）、HPV-52（每 1000 人月有 10.8 个新病例 [95% CI，8.2-14.1]）和 HPV-53（每 1000 人月有 9.8 个新病例 [95% CI， 7.4-13.0]），累积发生率 36 个月时相似于 30%。结论。 HIV 血清阳性 MSM 的肛管中常见多种 HPV 类型。不同 HPV 类型的发病率和清除率并不相似。对该队列的持续监测将有助于我们了解 HPV 持续存在和病变进展的决定因素。
Background. Human immunodeficiency virus (HIV)-seropositive men who have sex with men (MSM) are at higher risk of human papillomavirus (HPV) infection. This study was conducted to better understand the natural history of type-specific HPV infection in the anus.Methods. A cohort study was conducted among HIV-seropositive MSM in Montreal to investigate acquisition and loss of anal HPV infection. Participants were followed up every 6 months for 3 years for risk behaviors, HIV-related parameters, and HPV testing.Results. HPV DNA was detected in 97.9% of the 247 participants at baseline (median, 5 HPV types). The most common types were HPV-16 (38.2%) and HPV-6 (35.3%). Prevalent HPV-16 infections had the lowest clearance rate (12.2 cleared episodes per 1000 person-months [95% confidence interval {CI}, 8.5-17.7]) and a mean retention time of 36 months (95% CI, 32.7-38.8). The highest incidence rates were found for HPV-16 (10.8 new cases per 1000 person-months [95% CI, 8.0-14.7]), HPV-52 (10.8 new cases per 1000 person-months [95% CI, 8.2-14.1]), and HPV-53 (9.8 new cases per 1000 person-months [95% CI, 7.4-13.0]), with cumulative incidences at 36 months of similar to 30%.Conclusions. Multiple HPV types were common in the anal canals of HIV-seropositive MSM. Incidence and clearance rates were not similar among HPV types. Ongoing surveillance of this cohort will help our understanding of the determinants of HPV persistence and progression to lesions.