B Cells in Neuroinflammation: New Perspectives and Mechanistic Insights.
B Cells in Neuroinflammation: New Perspectives and Mechanistic Insights.
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DOI：
10.3390/cells10071605
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发表时间：
2021-06-26
期刊：
影响因子：
6
通讯作者：
Miller RH
中科院分区：
文献类型：
--
作者：
Ahn JJ;Abu-Rub M;Miller RH
近年来，B细胞在神经系统疾病中的作用大大扩展了我们对神经炎症机制的看法。B细胞消耗疗法在中枢神经系统疾病（如视神经脊髓炎和多发性硬化症）患者中的成功突出了炎症过程中神经免疫串音的重要性。虽然B细胞对适应性免疫系统和抗体产生至关重要，但在许多炎症性疾病中，它们也是促炎性和抗炎性细胞因子反应的主要贡献者。B细胞可以通过外周免疫机制，包括细胞因子和抗体的产生，或通过区隔化后的中枢神经系统机制，促进神经系统疾病。新出现的证据表明，异常的促炎或抗炎B细胞群有助于神经过程，包括神经胶质激活，这与几种神经退行性疾病的发病机制有关。在这篇综述中，我们总结了B细胞参与神经炎性疾病的最新发现，并讨论了支持B细胞在神经系统疾病中病原性免疫调节功能的证据，强调了B细胞定向治疗的重要性。
In recent years, the role of B cells in neurological disorders has substantially expanded our perspectives on mechanisms of neuroinflammation. The success of B cell-depleting therapies in patients with CNS diseases such as neuromyelitis optica and multiple sclerosis has highlighted the importance of neuroimmune crosstalk in inflammatory processes. While B cells are essential for the adaptive immune system and antibody production, they are also major contributors of pro- and anti-inflammatory cytokine responses in a number of inflammatory diseases. B cells can contribute to neurological diseases through peripheral immune mechanisms, including production of cytokines and antibodies, or through CNS mechanisms following compartmentalization. Emerging evidence suggests that aberrant pro- or anti-inflammatory B cell populations contribute to neurological processes, including glial activation, which has been implicated in the pathogenesis of several neurodegenerative diseases. In this review, we summarize recent findings on B cell involvement in neuroinflammatory diseases and discuss evidence to support pathogenic immunomodulatory functions of B cells in neurological disorders, highlighting the importance of B cell-directed therapies.
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影响因子：
11.2
作者：
Bennett, Jeffrey L.;Lam, Chiwah;Kalluri, Sudhakar Reddy;Saikali, Philippe;Bautista, Katherine;Dupree, Cecily;Glogowska, Magdalena;Case, David;Antel, Jack P.;Owens, Gregory P.;Gilden, Don;Nessler, Stefan;Stadelmann, Christine;Hemmer, Bernhard
通讯作者：
Hemmer, Bernhard
影响因子：
9.3
作者：
Chu, Tianci;Zhang, Yi Ping;Cai, Jun
通讯作者：
Cai, Jun
影响因子：
82.9
作者：
Alonso, AD;GrundkeIqbal, I;Iqbal, K
通讯作者：
Iqbal, K
影响因子：
15.9
作者：
Brochard, Vanessa;Combadiere, Behazine;Hunot, Stephane
通讯作者：
Hunot, Stephane
影响因子：
9.9
作者：
Besong-Agbo, Daniela;Wolf, Elias;Dodel, Richard
通讯作者：
Dodel, Richard