An evaluation of anaesthetic induction in healthy dogs using rapid intravenous injection of propofol or alfaxalone
An evaluation of anaesthetic induction in healthy dogs using rapid intravenous injection of propofol or alfaxalone
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DOI：
10.1111/j.1467-2995.2012.00747.x
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发表时间：
2013-03-01
影响因子：
1.7
通讯作者：
Pawson, Patricia
中科院分区：
文献类型：
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作者：
Amengual, Maria;Flaherty, Derek;Pawson, Patricia
研究设计前瞻性、随机、盲法临床研究动物60只健康犬（阿萨I/II）麻醉用于择期手术或诊断程序。方法术前用药为肌肉注射乙酰丙嗪（0.03 mg kg（-1））和哌替啶（哌替啶）（3 mg kg（-1））。对于麻醉诱导，狗通过快速IV注射接受3 mg kg（-1）丙泊酚（P组）或1.5 mg kg（-1）阿法沙酮（A组）。在诱导前、气管插管时和插管后3分钟和5分钟记录心率（HR）、呼吸频率（f（R））和动脉压。记录诱导后呼吸暂停或低血压的发生率。使用4分量表对诱导前镇静和诱导质量方面进行评分。结果两组患者的性别、年龄、体重、f（R）、诱导后呼吸暂停、动脉压、低血压、SpO（2）、镇静评分和诱导质量评分均无显著性差异（P> 0.05）。诱导时，P组HR降低（-2 +/-28次/分钟（-1）），但A组HR升高（14 +/-33次/分钟（-1）），差异显著（p = 0.047）。然而，术前用药后的HR变化在组间也存在差异（p = 0.006）。两组的动脉压均随时间显著降低，8只犬发生一过性低血压（P组5只，A组3只）。31只犬发生诱导后呼吸暂停（P组17只，A组14只）。需要额外的药物来实现气管插管在两个dogs.Conclusions和临床意义快速IV注射丙泊酚或阿法沙酮提供了合适的条件，在健康的狗气管插管，但诱导后呼吸暂停常见。
Objective To evaluate quality of anaesthetic induction and cardiorespiratory effects following rapid intravenous (IV) injection of propofol or alfaxalone.Study design Prospective, randomised, blinded clinical study.Animals Sixty healthy dogs (ASA I/II) anaesthetized for elective surgery or diagnostic procedures.Methods Premedication was intramuscular acepromazine (0.03 mg kg(-1)) and meperidine (pethidine) (3 mg kg(-1)). For anaesthetic induction dogs received either 3 mg kg(-1) propofol (Group P) or 1.5 mg kg(-1) alfaxalone (Group A) by rapid IV injection. Heart rate (HR), respiratory rate (f(R)) and oscillometric arterial pressures were recorded prior to induction, at endotracheal intubation and at 3 and 5 minutes post-intubation. The occurrence of post-induction apnoea or hypotension was recorded. Pre-induction sedation and aspects of induction quality were scored using 4 point scales. Data were analysed using Chi-squared tests, two sample t-tests and general linear model mixed effect ANOVA (p < 0.05).Results There were no significant differences between groups with respect to sex, age, body weight, f(R), post-induction apnoea, arterial pres-sures, hypotension, SpO(2), sedation score or quality of induction scores. Groups behaved differently over time with respect to HR. On induction HR decreased in Group P (-2 +/- 28 beats minute(-1)) but increased in Group A (14 +/- 33 beats minute(-1)) the difference being significant (p = 0.047). However HR change following premedication also differed between groups (p = 0.006). Arterial pressures decreased significantly over time in both groups and transient hypotension occurred in eight dogs (five in Group P, three in Group A). Post-induction apnoea occurred in 31 dogs (17 in Group P, 14 in Group A). Additional drug was required to achieve endotracheal intubation in two dogs.Conclusions and Clinical relevance Rapid IV injection of propofol or alfaxalone provided suitable conditions for endotracheal intubation in healthy dogs but post-induction apnoea was observed commonly.