Enhancement of striatum-dependent memory by conditioned fear is mediated by beta-adrenergic receptors in the basolateral amygdala.
Enhancement of striatum-dependent memory by conditioned fear is mediated by beta-adrenergic receptors in the basolateral amygdala.
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DOI：
10.1016/j.ynstr.2016.02.004
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发表时间：
2016-06
影响因子：
5
通讯作者：
Packard, Mark G
中科院分区：
文献类型：
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作者：
Goode, Travis D;Leong, Kah-Chung;Goodman, Jarid;Maren, Stephen;Packard, Mark G
情绪唤醒可以对各种学习和记忆过程产生深远的影响。例如，无条件的情绪刺激（例如，捕食者气味或焦虑药物）增强背外侧纹状体（DLS）依赖的习惯记忆。这些作用关键取决于杏仁核基底外侧复合体（BLA）的调节作用。最近的研究表明，像无条件的情绪刺激，暴露于厌恶条件刺激（CS）（即，先前与电击配对的音调）也可以增强DLS依赖性习惯记忆的巩固。本实验研究是否去甲肾上腺素能活性，特别是在BLA，是需要一个恐惧CS，以提高习惯记忆巩固。首先，大鼠进行了恐惧条件反射过程中，一个音CS配对的厌恶无条件刺激。在接下来的五天里，大鼠接受了一个依赖于DLS的水迷宫任务的训练，在这个任务中，大鼠被强化以做出一致的身体转向反应，以到达一个隐藏的逃避平台。在第1-3天的训练后，大鼠立即接受训练后全身（实验1）或BLA内（实验2）给予β-肾上腺素受体拮抗剂普萘洛尔。给药后立即将一半大鼠在条件反射环境中再次暴露于CS音调（无休克）。训练后CS曝光增强巩固的习惯记忆的车辆处理的大鼠，这种效果被封锁的外周（实验1）或内BLA（实验2）普萘洛尔管理。目前的研究结果表明，BLA内的去甲肾上腺素能活性是关键的DLS依赖的习惯记忆的增强作为暴露于条件性情绪刺激的结果。
Emotional arousal can have a profound impact on various learning and memory processes. For example, unconditioned emotional stimuli (e.g., predator odor or anxiogenic drugs) enhance dorsolateral striatum (DLS)-dependent habit memory. These effects critically depend on a modulatory role of the basolateral complex of the amygdala (BLA). Recent work indicates that, like unconditioned emotional stimuli, exposure to an aversive conditioned stimulus (CS) (i.e., a tone previously paired with shock) can also enhance consolidation of DLS-dependent habit memory. The present experiments examined whether noradrenergic activity, particularly within the BLA, is required for a fear CS to enhance habit memory consolidation. First, rats underwent a fear conditioning procedure in which a tone CS was paired with an aversive unconditioned stimulus. Over the course of the next five days, rats received training in a DLS-dependent water plus-maze task, in which rats were reinforced to make a consistent body-turn response to reach a hidden escape platform. Immediately after training on days 1–3, rats received post-training systemic (Experiment 1) or intra-BLA (Experiment 2) administration of the β-adrenoreceptor antagonist, propranolol. Immediately after drug administration, half of the rats were re-exposed to the tone CS in the conditioning context (without shock). Post-training CS exposure enhanced consolidation of habit memory in vehicle-treated rats, and this effect was blocked by peripheral (Experiment 1) or intra-BLA (Experiment 2) propranolol administration. The present findings reveal that noradrenergic activity within the BLA is critical for the enhancement of DLS-dependent habit memory as a result of exposure to conditioned emotional stimuli.