ASCARIS-LUMBRICOIDES - DETECTING ITS METABOLITES IN THE URINE OF INFECTED PEOPLE USING GAS-LIQUID-CHROMATOGRAPHY
ASCARIS-LUMBRICOIDES - DETECTING ITS METABOLITES IN THE URINE OF INFECTED PEOPLE USING GAS-LIQUID-CHROMATOGRAPHY
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DOI：
10.1016/0014-4894(90)90083-o
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发表时间：
1990-01-01
影响因子：
2.1
通讯作者：
ROMANOVA, T
中科院分区：
文献类型：
--
作者：
HALL, A;ROMANOVA, T
本文对蛔虫感染者尿液中溶出物进行了提取，并采用气液色谱法进行了检测。发现从尿液中提取的两种物质产生的峰面积与溶剂峰面积的比值与蠕虫负荷显著相关。通过红外分光光度法和质子磁共振光谱法对主要物质进行化学分析，表明其为2-甲基丁酰胺。另一种物质的化学性质表明它是2-甲基戊酰胺。这些物质很可能是两种酸的衍生物，已知这两种酸是蛔虫碳水化合物代谢的终产物。
Substances dissolved in the urine of people infected with Ascaris lumbricoides were extracted and detected by gas-liquid chromatography. The ratios of the areas of the peaks produced by two substances extracted from urine to the area of the peak of solvent were found to be significantly correlated with the worm burden. A chemical analysis of the predominant substance by infrared spectrophotometry and proton magnetic resonance spectrometry indicated that it was 2-methyl-butyramide. The chemical properties of the other substance indicated that it was 2-methyl-valeramide. These substances are likely to be derivatives of two acids known to be end products of the carbohydrate metabolism of Ascaris.