Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells.
Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells.
复制标题
氧化亚铜纳米颗粒选择性诱导肿瘤细胞凋亡。
DOI：
10.2147/ijn.s31133
复制
发表时间：
2012
影响因子：
8
通讯作者：
Hu YP
中科院分区：
文献类型：
--
作者：
Wang Y;Zi XY;Su J;Zhang HX;Zhang XR;Zhu HY;Li JX;Yin M;Yang F;Hu YP
随着纳米科学和纳米技术的迅速发展，许多研究人员发现金属氧化物纳米颗粒具有非常有用的药理作用。氧化亚铜纳米粒子（CONP）可以选择性地诱导肿瘤细胞凋亡，抑制肿瘤细胞增殖，在临床肿瘤治疗中显示出巨大的潜力。用C 0 NP处理引起肿瘤细胞的G1/G 0细胞周期停滞。此外，封闭在囊泡中的CONP进入线粒体或被线粒体摄取，这破坏了线粒体的膜，从而诱导细胞凋亡。CONP还可以产生活性氧（ROS）并引发脂质体膜的脂质过氧化，从而调节许多信号传导途径并影响细胞的生命运动。我们的研究结果表明，CONP对肿瘤细胞具有选择性的细胞毒性，并表明CONP可能是一个潜在的纳米药物治疗癌症。
In the rapid development of nanoscience and nanotechnology, many researchers have discovered that metal oxide nanoparticles have very useful pharmacological effects. Cuprous oxide nanoparticles (CONPs) can selectively induce apoptosis and suppress the proliferation of tumor cells, showing great potential as a clinical cancer therapy. Treatment with CONPs caused a G1/G0 cell cycle arrest in tumor cells. Furthermore, CONPs enclosed in vesicles entered, or were taken up by mitochondria, which damaged their membranes, thereby inducing apoptosis. CONPs can also produce reactive oxygen species (ROS) and initiate lipid peroxidation of the liposomal membrane, thereby regulating many signaling pathways and influencing the vital movements of cells. Our results demonstrate that CONPs have selective cytotoxicity towards tumor cells, and indicate that CONPs might be a potential nanomedicine for cancer therapy.