Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity.
Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity.
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DOI：
10.4103/0975-9476.96523
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发表时间：
2012-04-01
影响因子：
2.4
通讯作者：
Bhandari, Anil
中科院分区：
文献类型：
--
作者：
Bhati, Rajesh;Singh, Anupama;Bhandari, Anil
背景：马钱子俗称马钱子，主要成分为马钱子碱和马钱子碱。种子中存在的少量生物碱有原士的宁、马钱子碱、正士的宁、假士的宁、异士的宁、绿原酸和一种苷。传统上，种子被用来治疗糖尿病、哮喘、壮阳和改善食欲。目的：评价马钱子的各种生药学特性和抗糖尿病活性。材料与方法：按照世界卫生组织指南进行生药学研究。在石油醚、氯仿、醇、水醇、水溶液中进行提取，并通过不同的化学试验检测提取物中的植物化学成分。在四氧嘧啶诱导的糖尿病大鼠中，以格列齐特为标准，以水醇提取物和水醇提取物的提取率和植物成分为基础，评价其抗糖尿病活性。结果：建立了马钱子提取物的各种分析值。对马钱子提取物中的植物成分进行了检测。结论：马钱子提取物对实验动物具有抗高血糖作用。
BACKGROUND: Strychnos nux-vomica, commonly known as kuchla, contains strychnine and brucine as main constituents. Minor alkaloids present in the seeds are protostrychnine, vomicine, n-oxystrychnine, pseudostrychnine, isostrychnine, chlorogenic acid, and a glycoside. Seeds are used traditionally to treat diabetes, asthma, aphrodisiac and to improve appetite.OBJECTIVE: The present study was aimed to evaluate the various pharmacognostical characters and antidiabetic activity of S. nux-vomica seed.MATERIALS AND METHODS: Pharmacognostical characters were performed as per the WHO guideline. Extraction was carried out in petroleum ether, chloroform, alcohol, hydroalcoholic, aqueous, and phytochemical constituents present in extracts were detected by different chemical tests. Among these extracts hydroalcoholic, aqueous extracts were evaluated for antidiabetic activity on the basis of extractive yield and phytoconstituents, in alloxan-induced diabetic rats using gliclazide as standard.RESULTS: Various analytical values of S. nux-vomica extract were established. Phytoconstituents present in S. nux-vomica extracts were detected.CONCLUSION: S. nux-vomica extracts show antihyperglycemic activity in experimental animals.