Alternative measures of response to Pseudomonas aeruginosa infection in Drosophila melanogaster
Alternative measures of response to Pseudomonas aeruginosa infection in Drosophila melanogaster
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DOI：
10.1111/j.1420-9101.2006.01267.x
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发表时间：
2007-03-01
影响因子：
2.1
通讯作者：
Promislow, D. E. L.
中科院分区：
文献类型：
--
作者：
Corby-Harris, V.;Habel, K. E.;Promislow, D. E. L.
对无脊椎动物免疫防御的研究经常测量遗传变异，或者是感染的适应性成本，或者是宿主清除寄生虫的能力。这些研究假设，抗性措施的变化与感染的适应性成本的变化有关。为了验证这一假设，我们用致病细菌感染了果蝇（Drosophila melanogaster）。然后，我们测量了宿主细菌负荷和感染存活能力之间的相关性。尽管这两个性状存在基因型变异，但细菌负荷和感染后存活率不相关。我们的研究结果支持以前的论点，个别措施的免疫功能和宿主的能力，感染后的生存可能是解耦的。根据这些结果，我们认为，耐受性和抗感染，在植物文献中常见的区别之间的差异，也可能是无脊椎动物免疫研究的价值。
Studies of invertebrate immune defence often measure genetic variation either for the fitness cost of infection or for the ability of the host to clear the parasite. These studies assume that variation in measures of resistance is related to variation in fitness costs of infection. To test this assumption, we infected strains of the fruit fly, Drosophila melanogaster, with a pathogenic bacterium. We then measured the correlation between host bacterial load and the ability to survive infection. Despite the presence of genotypic variation for both traits, bacterial load and survival post-infection were not correlated. Our results support previous arguments that individual measures of immune function and the host's ability to survive infection may be decoupled. In light of these results, we suggest that the difference between tolerance and resistance to infection, a distinction commonly found in the plant literature, may also be of value in studies of invertebrate immunity.