Plasma phospholipid concentration of cis-palmitoleic acid and risk of heart failure.
Plasma phospholipid concentration of cis-palmitoleic acid and risk of heart failure.
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DOI：
10.1161/circheartfailure.112.967802
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Gaziano JM
中科院分区：
文献类型：
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作者：
Djoussé L;Weir NL;Hanson NQ;Tsai MY;Gaziano JM
虽然血浆棕榈油酸与血压、炎症和胰岛素抵抗呈正相关，但其与心力衰竭的相关性尚未研究。我们评估了血浆磷脂顺式棕榈油酸是否与心力衰竭风险相关。这项医生健康研究的辅助研究使用风险集抽样方法选择了788对配对。对于每例心力衰竭事件，我们在索引病例诊断时无心力衰竭且存活的受试者中随机选择对照，并在年龄，出生年份，种族和采血时间上匹配。采用气相色谱法测定血浆磷脂脂肪酸。心力衰竭通过年度随访问卷确定，并在子样本中验证。在多变量条件logistic回归中，顺式棕榈油酸连续四分位数的心力衰竭比值比（95% CI）分别为1.0（参考）、1.06（0.75-1.48）、1.20（0.85-1.68）和1.58（1.11-2.25）（趋势p <0.009）。在多变量模型中，血浆顺式棕榈油酸的每一个标准差增加与心力衰竭几率增加17%相关（95%CI：2%-33%）。在次要分析中，log-硬脂酰-CoA去饱和酶活性的每个标准差增加（16：1 n-7/16：0比率）与心力衰竭风险呈正相关[OR：1.14（95% CI：1.00-1.29）]，而油酸和顺式异油酸浓度与心力衰竭风险无关。我们的数据显示，男性医生的血浆磷脂顺式棕榈油酸与心力衰竭风险呈正相关。
While plasma palmitoleic acid has been positively associated with blood pressure, inflammation, and insulin resistance, its association with heart failure has not been investigated. We assessed whether plasma phospholipid cis palmitoleic acid was associated with heart failure risk. This ancillary study of the Physicians’ Health Study used a risk set sampling method to select 788 matched pairs. For each case of incident heart failure, we randomly selected a control among subjects that were free of heart failure and alive at the time of index case diagnosis and matched on age, year of birth, race, and time of blood collection. Plasma phospholipid fatty acids were measured using gas chromatography. Heart failure was ascertained using annual follow-up questionnaire and validated in a subsample. In a multivariable conditional logistic regression, odds ratios (95% CI) for heart failure were 1.0 (ref), 1.06 (0.75-1.48), 1.20 (0.85-1.68), and 1.58 (1.11-2.25) across consecutive quartiles of cis palmitoleic acid (p for trend 0.009). Each standard deviation increase in plasma cis palmitoleic acid was associated with 17% higher odds of heart failure (95% CI: 2% to 33%) in a multivariable model. In a secondary analysis, each standard deviation increase of log-stearoyl-coA desaturase activity (16:1n-7/16:0 ratio) was positively associated with the risk of heart failure [OR: 1.14 (95% CI: 1.00-1.29)] whereas oleic acid and cis-vaccenic acid concentrations were not related to heart failure risk. Our data showed a positive association between plasma phospholipid cis-palmitoleic acid and heart failure risk in male physicians.