Risk- and protective factors for memory plasticity in aging
Risk- and protective factors for memory plasticity in aging
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DOI：
10.1080/13825585.2020.1727834
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发表时间：
2020-02-27
影响因子：
1.9
通讯作者：
Walhovd, Kristine B.
中科院分区：
文献类型：
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作者：
Brathen, Anne Cecilie Sjoli;De Lange, Ann-Marie Glaso;Walhovd, Kristine B.
衰老中认知功能的风险和保护因素可能会影响个体通过保持或改善认知能力从环境或生活经历中受益的程度。我们调查了136名健康的年轻人和老年人的这些因素和情景记忆训练结果之间的关系。测试的风险因素包括携带载脂蛋白E等位基因（APOE）的e4变体，年龄，体重指数，血压和胆固醇。保护因素包括较高的教育水平、智商（IQ）、体育活动、脂肪酸和维生素D。训练后，记忆力表现平均有所提高，个体之间存在很大差异。年轻、女性、高智商是记忆力提高的积极预测因素。未观察到其他关系。在APOE等位基因变异中观察到类似的益处。这表明，除了智商，年龄和性别，已知的风险和保护因素的认知功能在老化没有显着相关的记忆可塑性。
Risk and protective factors for cognitive function in aging may affect how much individuals benefit from their environment or life experiences by preserving or improving cognitive abilities. We investigated the relations between such factors and outcome from episodic-memory training in 136 healthy young and older adults. Tested risk factors included carrying the e4 variant of the apolipoprotein E allele (APOE), age, body mass index, blood pressure, and cholesterol. Protective factors included higher levels of education, intelligence quotient (IQ), physical activity, fatty acids, and vitamin D. Average increases in memory performance were seen after training, with ample variation between individuals. Being young, female, and having higher IQ were positive predictors of memory improvement. No other relationships were observed. Similar benefit was observed across APOE allelic variation. This indicates that beyond IQ, age, and sex, known risk -and protective factors of cognitive function in aging were not significantly related to memory plasticity.