Epilepsy patients treated with antiepileptic drug therapy exhibit compromised ocular perfusion characteristics
Epilepsy patients treated with antiepileptic drug therapy exhibit compromised ocular perfusion characteristics
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DOI：
10.1046/j.1528-1157.2002.44901.x
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发表时间：
2002-11-01
期刊：
影响因子：
5.6
通讯作者：
Betts, T
中科院分区：
文献类型：
--
作者：
Hilton, EJR;Hosking, SL;Betts, T
目的：抗癫痫药物（AED）治疗的癫痫患者存在脑血流量减少和脑葡萄糖代谢降低。本研究的目的是确定是否眼血流动力学同样减少癫痫患者治疗AEDs.Methods：扫描激光多普勒血流仪被用来测量视网膜毛细血管微血管流量，体积和速度在颞神经视网膜边缘的14例诊断为癫痫（平均年龄42.0 +/- 0.9岁）。将这些值与年龄和性别匹配的正常受试者组（n = 14;平均年龄41.7 ± 0.3岁）的值进行比较。学生的受损双尾t检验被用来比较癫痫和正常受试者组之间的眼血流参数（p < 0.05; Bonferroni更正）。结果：视网膜血容量显著减少（p = 0.001），流量（p = 0.003）和速度（p = 0.001）在癫痫组中观察到与正常受试者组相比（分别为13.52 +/- 3.75 Au、219.14 +/- 76.61 Au和0.77 +/- 0.269 Au）（分别为19.02 +/- 5.11 Au、344.03 +/- 93.03 Au和1.17 +/- 0.301 Au）。总体而言，癫痫组与正常组之间的流量百分比平均差异为36.31%，体积百分比平均差异为28.92%，速度百分比平均差异为34.19%。结论：与正常人相比，癫痫患者的神经视网膜毛细血管血流量、体积和速度减少。眼灌注的减少可能对癫痫患者的视觉功能有影响。
Purpose: Reduced cerebral blood flow and decreased cerebral glucose metabolism have been identified in patients with epilepsy treated with antiepileptic drug (AED) therapy. The purpose of this study was to determine whether ocular haemodynamics are similarly reduced in patients with epilepsy treated with AEDs.Methods: Scanning laser Doppler flowmetry was used to measure retinal capillary microvascular flow, volume, and velocity in the temporal neuroretinal rim of 14 patients diagnosed with epilepsy (mean age, 42.0 +/- 0.9 years). These values were compared with those of an age- and gender-matched normal subject group (n = 14; mean age, 41.7 +/- 0.3 years). Student's Impaired two-tailed t tests were used to compare ocular blood-flow parameters between the epilepsy and normal subject groups (p < 0.05; Bonferroni corrected).Results: A significant reduction in retinal blood volume (p = 0.001), flow (p = 0.003), and velocity (p = 0.001) was observed in the epilepsy group (13.52 +/- 3.75 AU, 219.14 +/- 76.61 AU, and 0.77 +/- 0.269 AU, respectively) compared with the normal subject group (19.02 +/- 5.11 AU, 344.03 +/- 93.03 AU, and 1.17 +/- 0.301 AU, respectively). Overall, the percentage mean difference between the epilepsy and normal groups was 36.31% for flow, 28.92% for volume, and 34.19% for velocity.Conclusions: Patients with epilepsy exhibit reduced neuroretinal capillary blood flow, volume, and velocity compared with normal subjects. A reduction in ocular perfusion may have implications for visual function in people with epilepsy.