Heterogeneity in human melanoma cell adhesion to cytokine activated endothelial cells correlates with VLA-4 expression.
Heterogeneity in human melanoma cell adhesion to cytokine activated endothelial cells correlates with VLA-4 expression.
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人黑色素瘤细胞与细胞因子激活的内皮细胞粘附的异质性与 VLA-4 表达相关。
作者：
I. Martìn‐padura;R. Mortarini;D. Lauri;S. Bernasconi;F. Sánchez‐Madrid;G. Parmiani;A. Mantovani;A. Anichini;E. Dejana
肿瘤细胞与内皮细胞（EC）的附着是转移过程的关键步骤之一。先前有报道称，白细胞介素1对内皮细胞的处理可诱导促进肿瘤细胞黏附的膜分子表达。在本文中，我们报道从人转移性黑色素瘤中分离出的一组六个克隆在其与白细胞介素1激活的内皮细胞的黏附能力上呈现出显著的异质性。这与克隆的整合素VLA - 4表达相关。针对VLA - 4及其内皮配体INCAM110/VCAM - 1的抗体消除了白细胞介素1诱导的黑色素瘤细胞与内皮细胞黏附的增加。这些数据表明VLA - 4表达在肿瘤内存在异质性，并且这可能是肿瘤细胞在二次扩散过程中与内皮细胞相互作用的关键决定因素。
Tumor cell attachment to endothelial cells (EC) is one of the critical steps of the metastatic process. It was previously reported that interleukin 1 treatment of EC induces expression of membrane molecules that promote tumor cell adhesion. In this paper we report that a panel of six clones isolated from a human metastatic melanoma presented a marked heterogeneity in their ability to adhere to interleukin 1 activated EC. This was correlated with integrin VLA-4 expression by the clones. Antibodies directed to VLA-4 and to its endothelial ligand INCAM110/VCAM-1 abolished interleukin 1 induced increase in melanoma cell adhesion to EC. These data demonstrate intratumor heterogeneity in the expression of VLA-4 and that this can represent a crucial determinant of tumor cell interaction with EC during secondary spread.
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肿瘤细胞-内皮相互作用。
DOI：
--
发表时间：
1988
期刊：
The American journal of pathology
影响因子：
--
作者：
Rice,GE;GimbroneJr,MA;Bevilacqua,MP
通讯作者：
Bevilacqua,MP
影响因子：
56.9
作者：
BEVILACQUA, MP;STENGELIN, S;SEED, B
通讯作者：
SEED, B
小鼠肿瘤细胞与毛细血管内皮之间粘附的特异性：体内优先转移的体外相关性。
影响因子：
11.2
作者：
Auerbach,R;Lu,WC;Pardon,E;Gumkowski,F;Kaminska,G;Kaminski,M
通讯作者：
Kaminski,M
介导 CD11/CD18 缺陷型淋巴母细胞与培养的人内皮细胞粘附的表面蛋白的鉴定。
DOI：
10.1172/jci114668
发表时间：
1990
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Schwartz,BR;Wayner,EA;Carlos,TM;Ochs,HD;Harlan,JM
通讯作者：
Harlan,JM
影响因子：
56.9
作者：
RICE, GE;BEVILACQUA, MP
通讯作者：
BEVILACQUA, MP