Ironing out Ferroportin.
Ironing out Ferroportin.
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DOI：
10.1016/j.cmet.2015.09.006
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发表时间：
2015-11-03
期刊：
影响因子：
29
通讯作者：
Ganz T
中科院分区：
文献类型：
--
作者：
Drakesmith H;Nemeth E;Ganz T
维持组织中的生理铁浓度对于新陈代谢和宿主防御至关重要。十二指肠中的铁吸收、衰老红细胞中的铁再循环以及巨噬细胞和肝细胞中储存的铁动员构成了主要的铁流入血浆以分布到组织中，主要用于红细胞生成。所有铁转移到血浆都是通过铁输出体ferroportin发生的。功能性膜相关铁转运蛋白的浓度由其配体铁调节激素铁调素控制，并由服务于铁稳态、氧利用、宿主防御和红细胞生成的调节机制进行微调。关于ferroportin的结构和生物学的基本问题仍有待回答。
Maintaining physiologic iron concentrations in tissues is critical for metabolism and host defense. Iron absorption in the duodenum, recycling of iron from senescent erythrocytes, and iron mobilization from storage in macrophages and hepatocytes constitute the major iron flows into plasma for distribution to tissues, predominantly for erythropoiesis. All iron transfer to plasma occurs through the iron exporter ferroportin. The concentration of functional membrane-associated ferroportin is controlled by its ligand, the iron-regulatory hormone hepcidin, and fine-tuned by regulatory mechanisms serving iron homeostasis, oxygen utilization, host defense and erythropoiesis. Fundamental questions about the structure and biology of ferroportin remain to be answered.