PCR survey of Hox genes in the goldfish Carassius auratus auratus
PCR survey of Hox genes in the goldfish Carassius auratus auratus
复制标题
金鱼鲫鱼Hox基因的PCR调查
DOI：
10.1002/jez.b.21144
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发表时间：
2007-05-15
影响因子：
2.2
通讯作者：
Meyer, Axel
中科院分区：
文献类型：
--
作者：
Luo, Jing;Stadler, Peter F.;Meyer, Axel
大约1500万年前，在鲤科谱系中发生了四倍体化事件，导致了金鱼的出现。本文对鲫鱼鲫（Carassius auratus auratus）的Hox基因进行了PCR调查，以评估这种基因组重复的后果。毫不奇怪，金鱼的Hox基因簇的基因组组织与密切相关的斑马鱼（Danio rerio）相似。然而，金鱼显示出更多的近期假基因，其特征是indel。这些发现与假设一致，即剂量效应导致选择压力，在四倍体化事件后迅速沉默关键的发育调节因子。
A tetraploidization event took place in the cyprinid lineage leading to goldfishes about 15 million years ago. A PCR survey for Hox genes in the goldfish Carassius auratus auratus (Actinopterygii: Cyprinidae) was performed to assess the consequences of this genome duplication. Not surprisingly, the genomic organization of the Hox gene clusters of goldfish is similar to that of the closely related zebrafish (Danio rerio). However, the goldfish exhibits a much larger number of recent pseudogenes, which are characterized by indels. These findings are consistent with the hypothesis that dosage effects cause selection pressure to rapidly silence crucial developmental regulators after a tetraploidization event.