Electrorhythmogenesis and anaesthesia in a physiological mean field theory
Electrorhythmogenesis and anaesthesia in a physiological mean field theory
复制标题
DOI：
10.1016/j.neucom.2004.01.185
复制
发表时间：
2004-06-01
期刊：
影响因子：
6
通讯作者：
Cheng, K
中科院分区：
文献类型：
--
作者：
Bojak, I;Liley, DTJ;Cheng, K
我们解决八个偏微分，二维，非线性平均场方程，它描述了大量的皮质神经元的动力学。这些方程的线性化版本已被用于产生在人类EEG中观察到的强共振，特别是α节律（8-13 Hz），具有生理上合理的参数。我们扩展这些结果在这里通过数值求解完整的方程在一个皮质的现实大小，它接收适当的“有色”噪声作为额外的皮质输入。数值方法的简要总结。作为对未来应用的展望，我们解释了如何模拟GABA增强全身麻醉的效果，并给出了第一个结果。(C)2004 Elsevier B. V.保留所有权利。
We solve eight partial-differential, two-dimensional, nonlinear mean field equations, which describe the dynamics of large populations of cortical neurons. Linearized versions of these equations have been used to generate the strong resonances observed in the human EEG, in particular the alpha-rhythm (8-13 Hz), with physiologically plausible parameters. We extend these results here by numerically solving the full equations on a cortex of realistic size, which receives appropriately "colored" noise as extra-cortical input. A brief summary of the numerical methods is provided. As an outlook to future applications, we explain how the effects of GABA-enhancing general anaesthetics can be simulated and present first results. (C) 2004 Elsevier B.V. All rights reserved.