Indirect inputs to ventral temporal cortex of monkey: the influence of unit activity of alerting auditory input, interhemispheric subcortical visual input, reward, and the behavioral response.
Indirect inputs to ventral temporal cortex of monkey: the influence of unit activity of alerting auditory input, interhemispheric subcortical visual input, reward, and the behavioral response.
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猴子腹侧颞叶皮层的间接输入：警报听觉输入、半球间皮层下视觉输入、奖励和行为反应的单位活动的影响。
DOI：
10.1152/jn.1993.70.6.2215
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发表时间：
1993
影响因子：
2.5
通讯作者：
O'Neill,SG
中科院分区：
文献类型：
--
作者：
Ringo,JL;O'Neill,SG
1.本研究检查了行为猕猴的颞下和海马旁皮质记录的1，021个单一单位的非视觉和间接输入。2.为了更好地分离这些影响，使用了完全裂脑、裂交叉制备。当同侧眼被覆盖时，记录细胞外单单位活动。在记录过程中，猴子进行了一项视觉辨别任务，该任务包括一系列单一图像的呈现。3.当呈现之间的间隔随机变化（通常在4和15秒之间）时，这些细胞中约有四分之一对视觉图像开始前500毫秒响起的警报音作出反应。这种反应是由于音调的警告值，通过发现在每次试验结束时发出相同的音调，这些细胞没有反应。使用发光二极管对之间的交换作为警告信号（一个打开，另一个关闭，也是视觉刺激开始前500 ms）在许多单位中产生了类似的反应。这表明了警报信号的皮层下路径。在大多数情况下，警告响应是抑制性的，通常延迟相对于警告信号的发生，以更接近匹配的图像到达时间。4.令人惊讶的是，尽管猴子的裂脑状态得到了证实，但偶尔（约2%）的细胞显示出仅限于另一个半球的视觉呈现的反应。虽然这种皮层下的视觉输入远比直接的视觉输入弱，但它在统计学上是可靠的。重要的是，间接输入是刺激特异性的，可以形成有限的大脑半球间视觉传递的神经基础，就像在人类裂脑患者中看到的那样。5.同样罕见的是，细胞的活动时间与动物的行为反应有关。
1. This study examined nonvisual and indirect inputs to 1,021 single units recorded in inferotemporal and parahippocampal cortex of behaving macaques. 2. To better isolate these influences, a fully split-brain, split-chiasm preparation was used. Extracellular single-unit activity was recorded while the ipsilateral eye was covered. During the recordings the monkeys worked on a visual discrimination task that consisted of a series of presentations of single images. 3. When the interval between presentations was varied randomly (usually between 4 and 15 s) about one-quarter of these cells responded to an alerting tone sounded 500 ms before the onset of the visual image. That this response is due to the warning value of the tone was shown by finding that an identical tone sounded at the end of each trial produced no response from these cells. Use of an exchange between pairs of light-emitting diodes as a warning signal (one turned on as the other was turned off, also 500 ms before the visual stimulus onset) produced a similar response in many units. This indicates a subcortical route for the alerting signal. In most cases, warning responses were inhibitory, often delayed with respect to the warning signal occurrence to more nearly match the image arrival time. 4. Surprisingly, and despite the monkeys' confirmed split-brain status, occasional cells (approximately 2%) showed a response from a visual presentation limited to the other hemisphere. Although this subcortical visual input was far weaker than direct visual input, it was nonetheless statistically reliable. Importantly, the indirect input was stimulus specific and could form the neural basis for a limited interhemispheric visual transfer of the sort seen in human split-brain patients. 5. Also rarely, cells showed activity time locked to the animal's behavioral response.