Fully Automatic Software for Retinal Thickness in Eyes With Diabetic Macular Edema From Images Acquired by Cirrus and Spectralis Systems
Fully Automatic Software for Retinal Thickness in Eyes With Diabetic Macular Edema From Images Acquired by Cirrus and Spectralis Systems
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DOI：
10.1167/iovs.13-11762
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发表时间：
2013-11-01
影响因子：
4.4
通讯作者：
Jaffe, Glenn J.
中科院分区：
文献类型：
--
作者：
Lee, Joo Yong;Chiu, Stephanie J.;Jaffe, Glenn J.
目的.为了确定一种新的自动分割程序，杜克光学相干断层扫描视网膜分析程序（DOCTRAP），是否可以应用于光谱域光学相干断层扫描（SD-OCT）图像，从不同的商业可获得的SD-OCT糖尿病黄斑水肿（DME）的眼睛。一种新的分割框架被用来分割的视网膜，视网膜色素上皮细胞，和布鲁赫的膜上的图像从眼睛DME获得的两个SD-OCT系统，光谱或卷云高清晰度（HD）-OCT。厚度数据由DOCTRAP软件与光谱和卷云产生的比较。使用组内相关（ICC）评估测量一致性及其依赖性。分析中包括每台机器20名受试者的共40次SD-OCT扫描。光谱：由DOCTRAP和Spectralis测定的1 mm中心区域的平均厚度分别为463.8 ± 107.5 μ m和467.0 ± 108.1 μ m（ICC，0.999）。在周围区域也有高水平的一致性（达到3 mm）。云染天：DOCTRAP和Cirrus的1 mm中心区域的平均厚度分别为440.8 +/- 183.4 μ m和442.7 +/- 182.4 μ m（ICC，0.999）。由于1例受试者的Cirrus分割错误，周围区域（最大3 mm）的厚度一致性变化更大（ICC，0.734-0.999）。在手动校正误差后，周围区域的厚度一致性较高（ICC，0.997-1.000）。DOCTRAP可用于在OCT平台上比较DME患者的视网膜厚度。
PURPOSE. To determine whether a novel automatic segmentation program, the Duke Optical Coherence Tomography Retinal Analysis Program (DOCTRAP), can be applied to spectral-domain optical coherence tomography (SD-OCT) images obtained from different commercially available SD-OCT in eyes with diabetic macular edema (DME).METHODS. A novel segmentation framework was used to segment the retina, inner retinal pigment epithelium, and Bruch's membrane on images from eyes with DME acquired by one of two SD-OCT systems, Spectralis or Cirrus high definition (HD)-OCT. Thickness data obtained by the DOCTRAP software were compared with those produced by Spectralis and Cirrus. Measurement agreement and its dependence were assessed using intraclass correlation (ICC).RESULTS. A total of 40 SD-OCT scans from 20 subjects for each machine were included in the analysis. Spectralis: the mean thickness in the 1-mm central area determined by DOCTRAP and Spectralis was 463.8 +/- 107.5 mu m and 467.0 +/- 108.1 mu m, respectively (ICC, 0.999). There was also a high level agreement in surrounding areas (out to 3 mm). Cirrus: the mean thickness in the 1-mm central area was 440.8 +/- 183.4 mu m and 442.7 +/- 182.4 mu m by DOCTRAP and Cirrus, respectively (ICC, 0.999). The thickness agreement in surrounding areas (out to 3 mm) was more variable due to Cirrus segmentation errors in one subject (ICC, 0.734-0.999). After manual correction of the errors, there was a high level of thickness agreement in surrounding areas (ICC, 0.997-1.000).CONCLUSIONS. The DOCTRAP may be useful to compare retinal thicknesses in eyes with DME across OCT platforms.