Duration of poliovirus excretion and fts implications for acute flaccid paralysis surveillance: A review of the literature
Duration of poliovirus excretion and fts implications for acute flaccid paralysis surveillance: A review of the literature
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DOI：
10.1093/infdis/175.supplement_1.s176
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发表时间：
1997-02-01
影响因子：
6.4
通讯作者：
Pallansch, MA
中科院分区：
文献类型：
--
作者：
Alexander, JP;Gary, HE;Pallansch, MA
及时调查急性弛缓性麻痹儿童，收集粪便标本进行病毒分离，是用于检测野生脊髓灰质炎病毒循环的主要策略。为了确定粪便标本收集的最佳时间，回顾了1935年至1995年期间发表的野生和疫苗脊髓灰质炎病毒排泄研究。从可比研究中收集数据，创建数据散点图，并计算三阶回归线。数据表明，大多数先前未接种疫苗的婴儿和幼儿在3-4周内排出野生脊髓灰质炎病毒。然而，在先前接种过灭活脊髓灰质炎病毒疫苗、先前存在感染血清型抗体或先前肠道感染过同源脊髓灰质炎病毒的儿童中，病毒脱落的持续时间缩短。这些数据表明，瘫痪发作后14天是在瘫痪儿童中检测到野生脊髓灰质炎病毒排泄的概率最高的时间间隔。
Timely investigation of children with acute flaccid paralysis, with collection of stool specimens for virus isolation, is the primary strategy used to detect wild poliovirus circulation To determine the optimal timing of stool specimen collection, studies of wild and vaccine poliovirus excretion published between 1935 and 1995 were reviewed. Data were compiled from comparable studies, scatter plots of the data were created, and third-order regression lines were calculated. The data indicated that wild polioviruses were excreted by a majority of previously unvaccinated infants and young children for 3-4 weeks. The duration of viral shedding was reduced, however, among children who were previously vaccinated with inactivated poliovirus vaccine, who had preexisting antibodies to the infecting serotype, or who had previous intestinal infection with homologous poliovirus. These data suggest that the 14-day period after onset of paralysis is the interval with the highest probability of detecting wild poliovirus excretion in paralyzed children.