BASAL RELEASE OF NITRIC-OXIDE FROM AORTIC RINGS IS GREATER IN FEMALE RABBITS THAN IN MALE RABBITS - IMPLICATIONS FOR ATHEROSCLEROSIS
BASAL RELEASE OF NITRIC-OXIDE FROM AORTIC RINGS IS GREATER IN FEMALE RABBITS THAN IN MALE RABBITS - IMPLICATIONS FOR ATHEROSCLEROSIS
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DOI：
10.1073/pnas.89.23.11259
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发表时间：
1992-12-01
影响因子：
11.1
通讯作者：
CHAUDHURI, G
中科院分区：
文献类型：
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作者：
HAYASHI, T;FUKUTO, JM;CHAUDHURI, G
已知雌二醇对动脉粥样硬化的发展具有保护作用，但这种激素作用的机制尚不清楚。动脉粥样硬化发展的早期事件之一是巨噬细胞与内皮细胞的粘附，而一氧化氮（NO）会抑制这一过程。我们发现雌性兔子内皮完整的主动脉环的一氧化氮基础释放量高于雄性兔子。卵巢切除术可将循环雌二醇浓度和 NO 基础释放量降低至雄性兔子的水平。这些数据表明，内皮完整的主动脉环释放的基础 NO 取决于循环雌二醇浓度，并为雌二醇对动脉粥样硬化发展的保护作用提供了解释。
Estradiol is known to exert a protective effect against the development of atherosclerosis, but the mechanism of this hormonal action is unknown. One of the early events in the development of atherosclerosis is the adhesion of macrophages to endothelial cells, and nitric oxide (NO) inhibits this process. We show that basal release of NO is greater with endothelium-intact aortic rings from female rabbits than those from males. Oophorectomy diminishes both circulating estradiol concentration and basal release of NO to levels seen in male rabbits. These data establish that basal NO release from endothelium-intact aortic rings depends on circulating estradiol concentration and offer an explanation for the protective effect of estradiol against the development of atherosclerosis.